Role, mechanism, and application of N6-methyladenosine in hepatobiliary carcinoma

被引：0

作者：

Jia, Chen ^{[1
]}

Lang, Qing-Fu ^{[1
]}

Yin, Zhi-Jie ^{[1
]}

Sun, Jia ^{[1
]}

Meng, Qing-Hui ^{[1
]}

Pei, Tie-Min ^{[1
]}

机构：

[1] Harbin Med Univ, Affiliated Hosp 1, Dept Gen Surg, 23 Postal St, Harbin 150001, Heilongjiang, Peoples R China

来源：

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY | 2025年 / 17卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Hepatobiliary carcinoma; RNA modification; N6-methyladenosine; Therapeutic targets; Treatment; MESSENGER-RNA TRANSLATION; HEPATOCELLULAR-CARCINOMA; CANCER PROGRESSION; M(6)A MODIFICATION; DEMETHYLASE; METHYLATION; METTL14; PROTEIN; SUPPRESSES;

D O I：

10.4251/wjgo.v17.i6.105140

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatobiliary carcinoma is a frequently occurring and highly invasive cancer within the digestive tract, known for its rapid progression. Due to its difficult diagnosis and treatment in clinical practice, hepatobiliary carcinoma is a serious threat to human life and health. In recent years, the incidence of hepatobiliary carcinoma has gradually increased. N6-methyladenosine (m6A) modification, as a reversible post-transcriptional modification of the adenosine N6 site, is one of the most important RNA modifications in eukaryotes. Emerging research indicates that m6A affects the biological process of cells through the regulation of gene expression. m6A modification also plays a key role in the occurrence and development of various cancers. This review summarizes the role and mechanism of m6A modification in hepatobiliary carcinoma, and discussed its potential clinical application, so as to provide a theoretical reference for the individualized treatment of hepatobiliary carcinoma.

引用

页数：16

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