Serum and tissue light-chains as disease biomarkers and targets for treatment in AL amyloidosis

被引：3

作者：

Camerini, Lara ^{[1
]}

Aimo, Alberto ^{[1
,2
]}

Pucci, Angela ^{[3
]}

Castiglione, Vincenzo ^{[2
]}

Musetti, Veronica ^{[2
]}

Masotti, Silvia ^{[2
]}

Caponi, Laura ^{[3
]}

Vergaro, Giuseppe ^{[1
,2
]}

Passino, Claudio ^{[1
,2
]}

Clerico, Aldo ^{[1
,2
]}

Franzini, Maria ^{[3
]}

Emdin, Michele ^{[1
,2
]}

机构：

[1] Scuola Super Sant Anna, Piazza Martiri Liberta 33, I-56127 Pisa, Italy

[2] Fdn Toscana Gabriele Monasterio, Via Moruzzi 1, I-56124 Pisa, Italy

[3] Univ Hosp Pisa, I-56124 Pisa, Italy

来源：

VESSEL PLUS | 2022年 / 6卷

关键词：

Free light chains; AL amyloidosis; plasma cell disorder; heart failure; amyloid fibrils; immunoglobulin; CARDIAC BIOMARKERS; MASS-SPECTROMETRY; MULTIPLE-MYELOMA; ASSAYS; PEPTIDES; PROTEINS; MONOMERS; DIMERS; KAPPA;

D O I：

10.20517/2574-1209.2022.06

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amyloid light-chain (AL) amyloidosis is the most common type of systemic amyloidosis and is a multi-organ disease affecting mostly the heart and kidneys. AL amyloidosis is a protein misfolding disorder characterized by the tissue deposition of monoclonal light chains (LCs) produced by neoplastic plasma cells. Measurement of circulating free LC (FLC) is an important tool for diagnosis, risk stratification, and management of AL amyloidosis and can be performed through antibody-based methods or mass spectrometry. Furthermore, correct identification of LC deposits in tissues is essential to diagnose AL amyloidosis. Together with antibody-based techniques, methods on mass are now available.

引用

页数：10

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