Advances in chitosan based nanocarriers for targetted wound healing therapies: a review

被引:1
作者
Naveedunissa, S. [1 ]
Meenalotchani, R. [1 ]
Manisha, M. [2 ]
Singh, S. Ankul [2 ]
Nirenjen, S. [3 ]
Anitha, K. [4 ]
Harikrishnan, N. [5 ]
Prajapati, Bhupendra G. [6 ,7 ,8 ]
机构
[1] Dr MGR Educ & Res Inst, Dept Pharmaceut, Fac Pharm, Chennai 600077, Tamil Nadu, India
[2] Dr MGR Educ & Res Inst, Fac Pharm, Dept Pharmacol, Chennai 600077, Tamil Nadu, India
[3] SRM Inst Sci & Technol, SRM Coll Pharm, Dept Pharmacol, Kattankulathur 603203, Tamil Nadu, India
[4] DR MGR Educ & Res Inst, Fac Pharm, Dept Pharmaceut Chem, Chennai 600077, Tamil Nadu, India
[5] DR MGR Educ & Res Inst, Fac Pharm, Dept Pharmaceut Anal, Chennai 600077, Tamil Nadu, India
[6] Ganpat Univ, Shree SK Patel Coll Pharmaceut Educ & Res, Kherva 384012, Gujarat, India
[7] Silpakorn Univ, Dept Pharmacol & Toxicol, Fac Pharm, Sanam Chandra Palace Campus 6 Rajamankha Nai Rd, Bangkok 73000, Amphoe Muang Na, Thailand
[8] Chitkara Univ, Chitkara Coll Pharm, Ctr Res Impact & Outcome, Rajpura 140401, Punjab, India
来源
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS | 2025年 / 11卷
关键词
Wound healing; Chitosan nanoparticles; Controlled drug release; Antimicrobial activity; Surface modification strategies; DRUG-DELIVERY SYSTEM; IN-VITRO; CARBOXYMETHYL CHITOSAN; ANTIBACTERIAL ACTIVITY; CONTROLLED-RELEASE; NANOPARTICLES; HYDROGEL; OPPORTUNITIES; FORMULATION; CHALLENGES;
D O I
10.1016/j.carpta.2025.100891
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Wound healing is a critical physiological process essential for restoring tissue integrity and function. Chronic wounds, often characterized by prolonged inflammation, infection, and impaired tissue regeneration, pose significant challenges to global healthcare systems. Chitosan, a naturally derived polymer, has gained attention for its biocompatibility, biodegradability, and inherent antimicrobial properties. Incorporating chitosan into nanoparticle systems enhances its therapeutic potential by enabling controlled drug release, targeted delivery, and improved stability of bioactive agents. Chitosan nanoparticles (CSNPs) exhibit unique properties such as antimicrobial activity, facilitation of hemostasis, and immune modulation, collectively promoting wound healing. This review highlights the various techniques used for chitosan nanoparticle preparation, including ionic gelation, polyelectrolyte complexation, and emulsification-solvent diffusion, emphasizing their impact on encapsulation efficiency and drug release profiles. Additionally, advancements in surface modification strategies, such as PEGylation and ligand functionalization, have improved nanoparticle targeting capabilities. Despite their immense potential, challenges related to scalability, regulatory frameworks, and translational gaps remain significant barriers to widespread adoption. Future efforts should focus on overcoming these barriers to enable clinical translation and maximize therapeutic impact.
引用
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页数:15
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