Epidemiology and Steroid Dependency Reduction in Crohn's Disease During the Biologics Era: A Nationwide Population-Based Study

IntroductionCrohn's disease (CD), a subtype of inflammatory bowel disease, is a growing health concern. In this study, we examined the influence of biologics on prescription trends and steroid dependency.MethodsThis retrospective longitudinal analysis of insurance coverage spanned at least 1 year before and 1 year after the inflammatory bowel disease diagnosis and enrolled 4476 patients with CD. The study period was divided into the pre-biologics and post-biologics eras according to the date when the first CD-related prescription was issued. We examined prescription patterns, steroid dependency rates, and concurrent use of immunomodulators or biologics.ResultsThe CD incidence ranged from 1.6 to 1.3 cases per 100,000 patients between 2006 and 2018. During the pre-biologics era, the initial medications primarily comprised steroids (76.2%), followed by 5-aminosalicylic acid (44%) and immunomodulators (5.8%). During the post-biologics era, the initial prescription rates of steroids (69.8%) and 5-aminosalicylic acid (60.5%) remained high, and the Immunomodulators prescription rate increased to 14.7%. Steroid dependency was observed in 25.5 of 1000 and 22.1 of 1000 person-years during the pre-biologics and post-biologics eras, respectively. In the pre-biologics era, 6.1% of patients with steroid dependence received concurrent treatment with immunomodulators within the first 6 months. In the post-biologics era, this percentage increased to 24.2%, with some patients receiving immunomodulators or biologics.ConclusionsThe incidence rate in Taiwan showed a stable trend annually. Biologics approval and policy implementation resulted in increased immunomodulator use and decreased steroid dependency.