Drug analysis of a fatal case of bloodstream infection combined with urinary tract infection due to echinocandin-resistant Candida glabrata

被引：0
作者：
Wang, Linling [1 ]
Wang, Liangfen [1 ]
Liu, Man [1 ]
Ou, Yaqing [1 ]
Yang, Liang [1 ]
Chen, Rong [1 ]
机构：
[1] Genertec Med 363 Hosp, Dept Pharm, Chengdu, Peoples R China
来源：
IDCASES | 2025年 / 40卷
关键词：
Candida glabrata; Bloodstream infection; Urinary tract infection; Multidrug resistance; AMPHOTERICIN-B; FKS MUTATIONS; CASPOFUNGIN; FLUCONAZOLE; MICAFUNGIN; SUSCEPTIBILITY; FLUCYTOSINE; ALBICANS; THERAPY; FAILURE;
D O I：
10.1016/j.idcr.2025.e02261
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
When a urinary tract infection (UTI) progresses to a bloodstream infection (BSI), the choice of therapeutic drugs should consider their effectiveness against both BSI and UTI. C. glabrata exhibits strong resistance to antifungal drugs, making the treatment of BSI combined with UTI caused by this pathogen challenging. We report a fatal case of BSI combined with UTI caused by echinocandin-resistant C. glabrata in a 68-year-old female patient. The patient was treated with fluconazole, caspofungin, voriconazole, amphotericin B, and 5-flucytosine throughout the treatment process, but the infection was not controlled in the end. We analyzed the shortcomings in the medication process to provide some references for physicians in clinical treatment.
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页数：5
相关论文
共 37 条
[1]   Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations [J].
Alexander, Barbara D. ;
Johnson, Melissa D. ;
Pfeiffer, Christopher D. ;
Jimenez-Ortigosa, Cristina ;
Catania, Jelena ;
Booker, Rachel ;
Castanheira, Mariana ;
Messer, Shawn A. ;
Perlin, David S. ;
Pfaller, Michael A. .
CLINICAL INFECTIOUS DISEASES, 2013, 56 (12) :1724-1732
[2]  
程鹏, 2023, [中国真菌学杂志, Chinese Journal of Mycology], V18, P58
[3]   FKS Mutant Candida glabrata: Risk Factors and Outcomes in Patients With Candidemia [J].
Beyda, Nicholas D. ;
John, Julie ;
Kilic, Abdullah ;
Alam, Mohammad J. ;
Lasco, Todd M. ;
Garey, Kevin W. .
CLINICAL INFECTIOUS DISEASES, 2014, 59 (06) :819-825
[4]   Frequency of fks Mutations among Candida glabrata Isolates from a 10-Year Global Collection of Bloodstream Infection Isolates [J].
Castanheira, Mariana ;
Woosley, Leah N. ;
Messer, Shawn A. ;
Diekema, Daniel J. ;
Jones, Ronald N. ;
Pfaller, Michael A. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (01) :577-580
[5]   Acquired Flucytosine Resistance during Combination Therapy with Caspofungin and Flucytosine for Candida glabrata Cystitis [J].
Charlier, Caroline ;
El Sissy, Carine ;
Bachelier-Bassi, Sophie ;
Scemla, Anne ;
Quesne, Gilles ;
Sitterle, Emilie ;
Legendre, Christophe ;
Lortholary, Olivier ;
Bougnoux, Marie-Elisabeth .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (01) :662-665
[6]  
Chen N, 2011, Chin J Infect Chemother, V11, P119, DOI [10.16718/j.1009-7708.2011.02.031, DOI 10.16718/J.1009-7708.2011.02.031]
[7]  
陈亚玲, 2019, [中国艾滋病性病, Chinese Journal of Aids & STD], V25, P974
[8]  
Chinese Adult Candidiasis Diagnosis and Management Expert Consensus Group, 2020, Zhonghua Nei Ke Za Zhi, V59, P5, DOI 10.3760/cma.j.issn.0578-1426.2020.01.002
[9]   Impact of urinary tract infection-causative microorganisms on the progression to bloodstream infection: A propensity score-matched analysis [J].
Choi, Min Hyuk ;
Kim, Dokyun ;
Park, Yongjung ;
Jeong, Seok Hoon .
JOURNAL OF INFECTION, 2022, 85 (05) :513-518
[10]   First description of Candida nivariensis in Brazil: antifungal susceptibility profile and potential virulence attributes [J].
Galdino Figueiredo-Carvalho, Maria Helena ;
Ramos, Livia de Souza ;
Barbedo, Leonardo Silva ;
da Silva Chaves, Alessandra Leal ;
Muramoto, Ilda Akemi ;
Souza dos Santos, Andre Luis ;
Almeida-Paes, Rodrigo ;
Zancope-Oliveira, Rosely Maria .
MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2016, 111 (01) :51-58
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