Highly sensitive and selective β-Ni(OH)2@CNTs modified electrode for detection of Anti-Hepatitis C

This study presents a novel electrochemical electrode characterized by simplicity, sensitivity, rapidity, and curacy for quantifying daclatasvir hydrochloride (DCV) as an antiviral drug in pharmaceutical tablets and spiked human serum. The oxidation of DCV was carried out on the surface of a glassy carbon electrode (GCE), which treated with Beta-nickel hydroxide nanoparticles and carbon nanotubes ((3-Ni(OH)2 @ CNTS) at pH = 3.5 phosphate-buffered saline (PBS) solution, and applying a potential of 0.9 mV versus an Ag/AgCl reference electrode. Additionally, the surface and morphological properties of nanoparticles utilized in this study were analyzed through Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), and X-ray Diffraction (XRD), respectively. Furthermore, electrochemical analyses were performed utilizing cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The electrochemical method demonstrated linear ranges of 24.99-158.0 mu M, and 215.42-556.42 mu M. In addition to a limit of detection (LOD) of 0.0277 mM and 0.0958 mM for low and high concentration ranges, respectively. Compared to high-performance liquid chromatography (HPLC), this method offers advantages such as simplified sample preparation, rapid detection, and high sensitivity, making it a more attractive alternative for practical applications."