Mortalidad por SARS-CoV-2 (COVID-19) en pacientes oncológicos

被引：0

作者：

Hoyos-Pulgarin, Julian Andres ^{[1
]}

Gutierrez-Duran, Omar Armando ^{[2
]}

Castiblanco-Arroyave, Sara Camila ^{[3
]}

Fajardo-Torres, Katheryn ^{[4
]}

Correa-Castillo, Lina Clemencia ^{[5
]}

Garcia-Henao, Juan Pablo ^{[6
]}

Riveros-Bermudez, Sonia Dayana ^{[7
]}

机构：

[1] Oncologos Occidente, Pereira, Colombia

[2] Univ Tecnol Pereira, Pereira, Colombia

[3] Univ Libre Barranquilla, Barranquilla, Colombia

[4] Oncologos Occidente, Armenia, Colombia

[5] Oncologos Occidente, Manizales, Colombia

[6] Hosp Santa Mon, Dosquebradas, Colombia

[7] Oncologos Occidente, Pereira, Colombia

来源：

IATREIA | 2025年 / 38卷 / 02期

关键词：

Hematology; Mortality; Neoplasms; SARS-CoV-2; CORONAVIRUS DISEASE 2019; CANCER-PATIENTS; IMPACT; MALIGNANCIES; SEVERITY; COHORT; RISK;

D O I：

10.17533/udea.iatreia.312

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: SARS-CoV-2 infection represents a particular mortality risk for cancer patients. Objectives:To identify and describe the clinical and pathological characteristics associated with mortality in cancer patients infected with SARS-CoV-2. Methods: A retrospective, cross-sectional, analytical study was conducted between June 2020 and April 2021 across three hematology-oncology units. Results: A total of 274 patients with hematological or oncological malignancies who contracted the SARS-CoV-2 infection were identified. The overall mortality rate was 18.6%. Variables significantly associated with mortality included hematological neoplasms (p = 0.026), solid tumors (p = 0.021), leukemias (p = 0.011), symptoms such as fever, dyspnea, general malaise, and odynophagia, as well as comorbidities including moderate to severe kidney disease (p = 0.021), HIV infection (p = 0.032), and type 2 diabetes mellitus (p = 0.046). Multivariate analysis revealed that the presence of leukemia (OR 4.23; 95% CI: 1.10-16.0; p = 0.035), dyspnea (OR 9.58; 95% CI: 3.5925.3; p = 0.001), and HIV infection (OR 16.5; 95% CI: 1.10-247; p = 0.042) were independent predictors of SARS-CoV-2 mortality in cancer patients. Conclusions: SARS-CoV-2 mortality in cancer patients is higher than in the general population, with increased rates observed in patients with kidney disease, HIV, diabetes, and hematological malignancies.

引用

页码：254 / 265

页数：12

共 39 条

[21] What Is Different About Patients With Hematologic Malignancies? A Retrospective Cohort Study of Cancer Patients Referred to a Hospice Research Network [J].

LeBlanc, Thomas W. ;

Abernethy, Amy P. ;

Casarett, David J. .

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2015, 49 (03) :505-512

[22] COVID-19 mortality in patients with cancer on chemotherapy or other anticancer treatments: a prospective cohort study [J].

Lee, Lennard Y. W. ;

Cazier, Jean Baptiste ;

Angelis, Vasileios ;

Arnold, Roland ;

Bisht, Vartika ;

Campton, Naomi A. ;

Chackathayil, Julia ;

Cheng, Vinton W. T. ;

Curley, Helen M. ;

Fittall, Matthew W. ;

Freeman-Mills, Luke ;

Gennatas, Spyridon ;

Goel, Anshita ;

Hartley, Simon ;

Hughes, Daniel J. ;

Kerr, David ;

Lee, Alvin J. X. ;

Lee, Rebecca J. ;

McGrath, Sophie E. ;

Middleton, Christopher P. ;

Murugaesu, Nirupa ;

Newsom-Davis, Thomas ;

Okines, Alicia F. C. ;

Olsson-Brown, Anna C. ;

Palles, Claire ;

Pan, Yi ;

Pettengell, Ruth ;

Powles, Thomas ;

Protheroe, Emily A. ;

Purshouse, Karin ;

Sharma-Oates, Archana ;

Sivakumar, Shivan ;

Smith, Ashley J. ;

Starkey, Thomas ;

Turnbull, Chris D. ;

Varnai, Csilla ;

Yousaf, Nadia ;

Kerr, Rachel ;

Middleton, Gary .

LANCET, 2020, 395 (10241) :1919-1926

[23] COVID-19 prevalence and mortality in patients with cancer and the effect of primary tumour subtype and patient demographics: a prospective cohort study [J].

Lee, Lennard Y. W. ;

Cozier, Jean-Baptiste ;

Starkey, Thomas ;

Briggs, Sarah E. W. ;

Arnold, Roland ;

Bisht, Vartika ;

Booth, Stephen ;

Campton, Naomi A. ;

Cheng, Vinton W. T. ;

Collins, Graham ;

Curley, Helen M. ;

Earwaker, Philip ;

Fittall, Matthew W. ;

Gennatas, Spyridon ;

Goel, Anshita ;

Hartley, Simon ;

Hughes, Daniel J. ;

Kerr, David ;

Lee, Alvin J. X. ;

Lee, Rebecca J. ;

Lee, Siow Ming ;

Mckenzie, Hayley ;

Middleton, Chris P. ;

Murugaesu, Nirupa ;

Newsom-Davis, Tom ;

Olsson-Brown, Anna C. ;

Palles, Claire ;

Powles, Thomas ;

Protheroe, Emily A. ;

Purshouse, Karin ;

Sharma-Oates, Archana ;

Sivakumar, Shivan ;

Smith, Ashley J. ;

Topping, Oliver ;

Turnbull, Chris D. ;

Varnai, Csilla ;

Briggs, Adam D. M. ;

Middletont, Gary ;

Kerr, Rachel .

LANCET ONCOLOGY, 2020, 21 (10) :1309-1316

[24] Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China [J].

Liang, Wenhua ;

Guan, Weijie ;

Chen, Ruchong ;

Wang, Wei ;

Li, Jianfu ;

Xu, Ke ;

Li, Caichen ;

Ai, Qing ;

Lu, Weixiang ;

Liang, Hengrui ;

Li, Shiyue ;

He, Jianxing .

LANCET ONCOLOGY, 2020, 21 (03) :335-337

[25] Risk factors for Coronavirus Disease 2019 (COVID-19) severity and mortality among solid cancer patients and impact of the disease on anticancer treatment: A French nationwide cohort study (GCO-002 CACOVID-19) [J].

Lievre, Astrid ;

Turpin, Anthony ;

Ray-Coquard, Isabelle ;

Le Malicot, Karine ;

Thariat, Juliette ;

Ahle, Guido ;

Neuzillet, Cindy ;

Paoletti, Xavier ;

Bouche, Olivier ;

Aldabbagh, Kais ;

Michel, Pierre ;

Debieuvre, Didier ;

Canellas, Anthony ;

Wislez, Marie ;

Laurent, Lucie ;

Mabro, May ;

Colle, Raphael ;

Hardy-Bessard, Anne-Claire ;

Mansi, Laura ;

Colomba, Emeline ;

Bourhis, Jean ;

Gorphe, Philippe ;

Pointreau, Yoann ;

Idbaih, Ahmed ;

Ursu, Renata ;

Di Stefano, Anna Luisa ;

Zalcman, Gerard ;

Aparicio, Thomas .

EUROPEAN JOURNAL OF CANCER, 2020, 141 :62-81

[26] The Impact of COVID-19 Pandemic in Portuguese Cancer Patients: A Retrospective Study [J].

Lima, Aurea ;

Sousa, Hugo ;

Nobre, Amanda ;

Faria, Ana Luisa ;

Machado, Manuela .

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, 18 (16)

[27] COVID-19 in cancer patients: risk, clinical features, and management [J].

Liu, Cuiwei ;

Zhao, Yanxia ;

Okwan-Duodu, Derick ;

Basho, Reva ;

Cuis, Xiaojiang .

CANCER BIOLOGY & MEDICINE, 2020, 17 (03) :519-527

[28] Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding [J].

Lu, Roujian ;

Zhao, Xiang ;

Li, Juan ;

Niu, Peihua ;

Yang, Bo ;

Wu, Honglong ;

Wang, Wenling ;

Song, Hao ;

Huang, Baoying ;

Zhu, Na ;

Bi, Yuhai ;

Ma, Xuejun ;

Zhan, Faxian ;

Wang, Liang ;

Hu, Tao ;

Zhou, Hong ;

Hu, Zhenhong ;

Zhou, Weimin ;

Zhao, Li ;

Chen, Jing ;

Meng, Yao ;

Wang, Ji ;

Lin, Yang ;

Yuan, Jianying ;

Xie, Zhihao ;

Ma, Jinmin ;

Liu, William J. ;

Wang, Dayan ;

Xu, Wenbo ;

Holmes, Edward C. ;

Gao, George F. ;

Wu, Guizhen ;

Chen, Weijun ;

Shi, Weifeng ;

Tan, Wenjie .

LANCET, 2020, 395 (10224) :565-574

[29]

NCCN, 2020, Coronavirus disease 2019 (COVID-19) resources for the cancer care community Internet

[30] Impact of COVID-19 Infection on Patients with Cancer: Experience in a Latin American Country: The ACHOCC-19 Study [J].

Ospina, Aylen Vanessa ;

Bruges, Ricardo ;

Mantilla, William ;

Triana, Ivan ;

Ramos, Pedro ;

Aruachan, Sandra ;

Quiroga, Alicia ;

Munevar, Isabel ;

Ortiz, Juan ;

Llinas, Nestor ;

Pinilla, Paola ;

Vargas, Henry ;

Idrobo, Henry ;

Russi, Andrea ;

Kopp, Ray Manneh ;

Rivas, Giovanna ;

Gonzalez, Hector ;

Santa, Daniel ;

Insuasty, Jesus ;

Bernal, Laura ;

Otero, Jorge ;

Vargas, Carlos ;

Pacheco, Javier ;

Alcala, Carmen ;

Jimenez, Paola ;

Lombana, Milton ;

Contreras, Fernando ;

Segovia, Javier ;

Pino, Luis ;

Lobaton, Jose ;

Gonzalez, Manuel ;

Cuello, Javier ;

Bogoya, Juliana ;

Barrero, Angela ;

de Lima Lopes, Gilberto, Jr. .

ONCOLOGIST, 2021, 26 (10) :E1761-E1773

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