Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

被引：0

作者：

Van Hove, Hannah ^{[1
]}

Gluck, Chaim ^{[3
]}

Mildenberger, Wiebke ^{[1
]}

Petrova, Ekaterina ^{[1
]}

Maheshwari, Upasana ^{[2
]}

Hane, Philipp ^{[1
]}

Kreiner, Victor ^{[1
]}

Bijnen, Mitchell ^{[1
]}

Mussak, Caroline ^{[1
]}

Utz, Sebastian G. ^{[1
]}

Droux, Jeanne ^{[3
,4
,5
]}

Ingelfinger, Florian ^{[1
]}

Ashworth, Christian ^{[1
]}

Stifter, Sebastian A. ^{[1
]}

Roussel, Elsa ^{[1
]}

Lelios, Iva ^{[1
,6
,7
]}

Vermeer, Marijne ^{[1
,6
,7
]}

Huang, Sheng-Fu ^{[2
]}

Zhou, Quanyu ^{[6
,7
,8
]}

Chen, Zhenyue ^{[8
]}

Calvet, Charlotte ^{[9
]}

Bourgeois, Soline ^{[9
]}

Schaffenrath, Johanna ^{[2
,10
,11
]}

Razansky, Daniel ^{[8
,9
]}

Juang, Jean X. ^{[12
]}

Asano, Kenichi ^{[13
]}

Pelczar, Pawel ^{[14
]}

Mundt, Sarah ^{[1
]}

Weber, Bruno ^{[3
]}

Wegener, Susanne ^{[4
,5
]}

Tugues, Sonia ^{[1
]}

Stockmann, Christian ^{[15
]}

Becher, Burkhard ^{[1
]}

Keller, Annika ^{[2
,10
,11
]}

El Amki, Mohamad ^{[3
,4
,5
]}

Greter, Melanie ^{[1
]}

机构：

[1] Univ Zurich, Inst Expt Immunol, Zurich, Switzerland

[2] Univ Zurich, Univ Hosp Zurich, Clin Neurosci Ctr, Dept Neurosurg, Zurich, Switzerland

[3] Univ Zurich, Inst Pharmacol & Toxicol, Expt Imaging & Neuroenerget, Zurich, Switzerland

[4] Univ Hosp Zurich, Dept Neurol, Zurich, Switzerland

[5] Univ Zurich, Zurich, Switzerland

[6] Univ Zurich, Fac Med, Inst Biomed Engn, Zurich, Switzerland

[7] Univ Zurich, Inst Pharmacol & Toxicol, Fac Med, Zurich, Switzerland

[8] Swiss Fed Inst Technol, Inst Biomed Engn, Dept Informat Technol & Elect Engn, Zurich, Switzerland

[9] Univ Zurich, Inst Physiol, Zurich, Switzerland

[10] Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland

[11] Swiss Fed Inst Technol, Zurich, Switzerland

[12] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem & Struct Biol, San Antonio, TX 78229 USA

[13] Tokyo Univ Pharm & Life Sci, Sch Life Sci, Lab Immune Regulat, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan

[14] Univ Basel, Ctr Transgenic Models, Basel, Switzerland

[15] Univ Zurich, Inst Anat, Zurich, Switzerland

来源：

IMMUNITY | 2025年 / 58卷 / 05期

基金：

瑞士国家科学基金会; 欧洲研究理事会;

关键词：

COLONY-STIMULATING FACTOR-1; PROGENITOR-CELL; LANGERHANS CELLS; ANALYSIS REVEALS; MICROGLIA; RECEPTOR; FATE; IMMUNE; HEALTH; MAINTENANCE;

D O I：

10.1016/j.immuni.2025.04.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of most macrophages depends on the colony-stimulating factor 1 (CSF-1) receptor, which has two ligands: CSF-1 and interleukin-34 (IL-34). While IL-34 is required for the homeostasis of microglia, the parenchymal macrophages in the central nervous system (CNS), it is unclear whether brain border-associated macrophages (BAMs) also depend on this cytokine. Here, we demonstrated that the embryonic development of murine BAMs in the choroid plexus, leptomeninges, and perivascular spaces required CSF-1, while IL-34 was critical for their maintenance in adulthood. In the brain, Il34 was expressed by mural cells and perivascular fibroblasts, and its transgenic deletion in these cells interrupted BAM maintenance. Il34 deficiency coincided with transcriptional changes in vascular cells, leading to increased flow velocity and vasomotion in pial and penetrating arterioles. Similarly, Mrc1CreCsf1rfl/fl mice lacking CD206+ perivascular BAMs exhibited increased hemodynamics in arterial networks. These findings reveal a crosstalk between vascular cells and CNS macrophages regulating cerebrovascular function.

引用

页码：1289 / 1305.e8

页数：26

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