Treatment of Homozygous Familial Hypercholesterolemia With Evinacumab

被引：7

作者：

Jeraj, Natasha ^{[1
]}

Huang, Shih-Han S. ^{[1
]}

Kennedy, Brooke A. ^{[2
]}

Hegele, Robert A. ^{[1
,2
,3
]}

机构：

[1] Western Univ, Schulich Sch Med & Dent, Dept Med, London, ON, Canada

[2] Western Univ, Robarts Res Inst, Schulich Sch Med & Dent, London, ON, Canada

[3] Western Univ, Schulich Sch Med & Dent, Dept Biochem, London, ON, Canada

来源：

CJC OPEN | 2022年 / 4卷 / 03期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/j.cjco.2021.11.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with homozygous familial hypercholesterolemia (HoFH) have extremely elevated levels of low-density lipoprotein cholesterol (LDL-C), with premature atherosclerosis and aortic valve disease. Available drug treatments are inadequate, and even with serial apheresis, HoFH patients rarely achieve acceptable LDL-C levels. Evinacumab is a monoclonal antibody against angiopoietin-like protein 3 that lowers LDL-C via a novel receptor-independent mechanism. We describe an Ontario patient with HoFH who for 17 months has been treated with monthly infusions of evinacumab added to pre-existing statin, ezetimibe, and evolocumab therapy. Evinacumab in this HoFH patient was associated with markedly improved LDL-C levels and decreased frequency of apheresis.

引用

页码：347 / 349

页数：3

共 5 条

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