Chinese Expert Consensus on Integrated Chinese and Western Medicine for the Treatment of Tic Disorders

被引：0

作者：

Ma, Rong ^{[1
]}

Wang, Sumei ^{[2
]}

Zheng, Yi ^{[3
]}

Chen, Jian ^{[4
]}

Chen, Wenxiong ^{[5
]}

Cui, Xia ^{[6
]}

Cui, Yonghua ^{[7
]}

Guo, Yanzhao ^{[8
]}

Han, Fei ^{[9
]}

Han, Xinmin ^{[10
]}

Wang, Daohan ^{[2
]}

He, Fan ^{[3
]}

Rong, Ping ^{[1
]}

Hu, Yan ^{[7
]}

Huang, Yi ^{[11
]}

Ke, Xiaoyan ^{[12
]}

Li, Bo ^{[13
]}

Li, Min ^{[14
]}

Li, Ruiben ^{[1
]}

Liu, Huanzhong ^{[15
]}

Liu, Jing ^{[16
]}

Liu, Zhisheng ^{[17
]}

Luo, Xuerong ^{[18
]}

Ma, Bingxiang ^{[19
]}

Shi, Ping ^{[20
]}

Sun, Jiaxin ^{[1
]}

Wang, Hua ^{[21
]}

Wu, Liping ^{[22
]}

Wu, Min ^{[23
]}

Yan, Haihong ^{[24
]}

Zhang, Baoqing ^{[25
]}

Zhang, Jinsong ^{[23
]}

Zhang, Junhua ^{[26
]}

Zhang, Xilian ^{[1
]}

Zhang, Xin ^{[23
]}

机构：

[1] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Dept Pediat, Tianjin, Peoples R China

[2] Beijing Univ Chinese Med, Dongfang Hosp, Dept Pediat, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Anding Hosp, Dept Pediat Psychiat, Beijing, Peoples R China

[4] Zhejiang Univ Chinese Med, Hosp Management Off, Hangzhou, Zhejiang, Peoples R China

[5] Guangzhou Women & Childrens Med Ctr, Dept Behav Dev, Guangzhou, Peoples R China

[6] Beijing Univ Chinese Med, Affiliated Hosp 3, Dept Pediat, Beijing, Peoples R China

[7] Capital Med Univ, Beijing Childrens Hosp, Dept Psychiat, Beijing, Peoples R China

[8] Xian Encephalopathy Hosp Tradit Chinese Med, Ten Dept Encephalopathy, Xian, Peoples R China

[9] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Pediat, Beijing, Peoples R China

[10] Jiangsu Prov Hosp Tradit Chinese Med, Dept Pediat, Nanjing, Peoples R China

[11] Sichuan Univ, West China Hosp, Dept Psychiat, Chengdu, Peoples R China

[12] Nanjing Med Univ, Affiliated Brain Hosp, Childrens Psychohyg Res Ctr, Nanjing, Peoples R China

[13] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Gastroenterol, Beijing, Peoples R China

[14] Capital Inst Pediat, Childrens Hosp, Dept Tradit Chinese Med, Beijing, Peoples R China

[15] Anhui Med Univ, Dept Psychiat, Chaohu Hosp, Chaohu, Peoples R China

[16] Peking Univ Sixth Hosp, Dept Pediat, Beijing, Peoples R China

[17] Wuhan Maternal & Child Hlth Hosp, Dept Pediat Neurol, Wuhan, Peoples R China

[18] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Peoples R China

[19] Henan Univ TCM, Affiliated Hosp 1, Childrens Brain Dis Diag & Rehabil Ctr, Zhengzhou, Peoples R China

[20] Tianjin Childrens Hosp, Dept Psychol, Tianjin, Peoples R China

[21] China Med Univ, Shengjing Hosp, Dept Pediat Neurol, Shenyang, Peoples R China

[22] Gansu Univ Chinese Med, Affiliated Hosp, Dept Pediat, Lanzhou, Peoples R China

[23] Shanghai Jiao Tong Univ Med, Xinhua Hosp, Dept Psychol, Sch Med, Shanghai, Peoples R China

[24] Childrens Hosp, Dept Tradit Chinese Med, Taiyuan, Shanxi, Peoples R China

[25] Shangdong Univ Chinese Med, Affiliated Hosp, Dept Pediat, Jinan, Peoples R China

[26] Tianjin Univ Tradit Chinese Med, Evidence Based Med Ctr, Tianjin, Peoples R China

来源：

JOURNAL OF EVIDENCE BASED MEDICINE | 2025年 / 18卷 / 02期

基金：

中国国家自然科学基金;

关键词：

expert consensus; integrated Chinese and Western medicine; tic disorders; traditional Chinese medicine; PLACEBO-CONTROLLED TRIAL; CONTROLLED DOUBLE-BLIND; TOURETTE SYNDROME; NINGDONG GRANULE; CHILDREN; LEVETIRACETAM; EFFICACY; SAFETY; ARIPIPRAZOLE; CLONIDINE;

D O I：

10.1111/jebm.70012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

ObjectiveTic disorders are neurodevelopmental conditions that manifest in childhood or adolescence and can significantly impact the quality of life of affected children and their families to varying degrees. Integrated traditional Chinese and Western medicine treatment strategies have demonstrated more pronounced efficacy and better safety profiles. However, there is currently no standardized clinical expert consensus on this approach. To address this, the National Administration of Traditional Chinese Medicine initiated a project, and the China Association of Chinese Medicine assembled a team of authoritative domestic experts to develop this expert consensus, aiming to provide practical and feasible integrated treatment strategies for clinical practice.MethodsThis consensus identified clinical issues through research, conducted literature reviews, and established evidence based on systematic evaluations. Expert surveys, two rounds of Delphi questionnaires, and expert consensus meetings were conducted to formulate a series of recommendations.ResultsWe established a multidisciplinary consensus development panel. Based on systematic literature reviews, Delphi questionnaires, and consensus meetings, ten clinical issues were identified. Ultimately, a series of recommendations were developed, considering the balance of benefits and risks, the certainty of evidence, clinical feasibility, accessibility, and clinical acceptability.ConclusionsThese recommendations comprehensively address key issues in the field of integrated traditional Chinese and Western medicine treatment, including indications for the use of Chinese or Western medicine alone or in combination, specific treatment protocols, methods for dose reduction and discontinuation, evaluation intervals, and the management of adverse reactions.

引用

页数：14

共 96 条

[1]

[Anonymous], 2007, A Randomized, DoubleBlind, PlaceboControlled

[2]

[Anonymous], 2017, A Phase 2b, Randomized, DoubleBlind, PlaceboControlled, Dose Optimization Study to Assess the Safety, Tolerability, and Efficacy of NBI98854 for the Treatment of Pediatric Subjects With Tourette Syndrome Internet

[3]

[Anonymous], 2016, A Randomized, DoubleBlind, PlaceboControlled Study to Assess the Safety and Efficacy of NBI98854 in Pediatric Subjects With Tourette Syndrome Internet

[4]

[Anonymous], 2018, A WellControlled, FixedDose Study of TEV50717 (Deutetrabenazine) for the Treatment of Tics Associated With Tourette Syndrome Internet

[5]

[Anonymous], 2018, A Multicenter, Randomized, DoubleBlind, FlexibleDosed, PlaceboControlled, ParallelGroup Clinical Trial Evaluating the Efficacy and Safety of Aripiprazole Oral Solution in Children and Adolescents With Tourette's Syndrome Internet

[6]

[Anonymous], 2018, A Randomized, Doubleblind, PlaceboControlled Study of TEV50717 (Deutetrabenazine) for the Treatment of Tourette Syndrome in Children and Adolescents Internet

[7]

[Anonymous], 2018, A Randomized, PlaceboControlled Trial to Evaluate the LongTerm (ie, Maintenance) Efficacy of Oral Aripiprazole in the Treatment of Pediatric Subjects With Tourette's Disorder Internet

[8]

Awaad YM, 2010, EUR J NEUROL, V17, P113

[9] N-Acetylcysteine in the Treatment of Pediatric Tourette Syndrome: Randomized, Double-Blind, Placebo-Controlled Add-On Trial [J].

Bloch, Michael H. ;

Panza, Kaitlyn E. ;

Yaffa, Alisa ;

Alvarenga, Pedro G. ;

Jakubovski, Ewgeni ;

Mulqueen, Jilian M. ;

Landeros-Weisenberger, Angeli ;

Leckman, James F. .

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 2016, 26 (04) :327-334

[10]

Cao M. H., 2019, Journal of Pediatrics of Traditional Chinese Medicine, V15, P71

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