Microwave-assisted Synthesis of Quinolines

Quinoline is a biologically important class of N-based heterocyclic compound. It has attracted the attention of the researchers since the 19th century. The researchers have identified more than 600 quinoline compounds to date. Further, these exhibit several biological activities such as antibacterial, antifungal, antimalarial, antiviral, anti-inflammatory, antiparasitic, insecticidal, and other activities. Microwave-assisted synthesis is a promising green technique for synthesizing organic and heterocyclic compounds. The present review provides an overview of the literature available on microwave-promoted synthetic methodologies for the synthesis of quinoline derivatives that have appeared in the last ten years. Since the major goal of this work is to highlight the sustainable nature of microwave-promoted methods, the green features of each research report are presented. It covers recent synthetic strategies both under homogeneous and heterogeneous catalytic approaches. Significant decreases in reaction times, enhancement in overall yields, and greater atom economy can be observed in the documented research. We believe that this work will definitely help in the search for novel and environmentally benign routes for the synthesis of quinoline-related potential lead molecules.