Role of Transcription Factor Fli-1 in Inflammation and Autoimmune Diseases

被引：0
作者：
Wang, Xuan [1 ,2 ,3 ]
Zhang, Xian K. [3 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Gen Practice, Changsha 410008, Peoples R China
[2] Xiangya Hosp, Int Joint Res Ctr Med Metab, Changsha 410008, Peoples R China
[3] Med Univ South Carolina, Dept Med, Div Rheumatol & Immunol, Charleston, SC 29403 USA
来源：
BIOMOLECULES | 2025年 / 15卷 / 04期
基金：
中国博士后科学基金; 湖南省自然科学基金; 中国国家自然科学基金;
关键词：
Fli-1; inflammatory mediator; transcriptional factor; cytokine; chemokine; autoimmune disease; VIRUS INTEGRATION 1; ENDOTHELIAL-CELLS; DOWN-REGULATION; ETS FAMILY; FLI-1-DRIVEN REGULATION; DEFICIENCY CONTRIBUTES; DERMAL FIBROBLASTS; LUPUS NEPHRITIS; EXPRESSION; GENE;
D O I：
10.3390/biom15040480
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Friend leukemia virus integration 1 (Fli-1), a member of the ETS family of transcription factors, plays an essential role in diverse biological processes. Recent studies have underscored the significance of Fli-1 in modulating inflammation and autoimmune diseases via the regulation of inflammatory responses. Specifically, Fli-1 exerts control over inflammatory processes, influencing key effectors and signaling pathways associated with conditions such as systemic lupus erythematosus, scleroderma, cancer, and sepsis. This review aims to summarize the emerging roles of Fli-1 in inflammation and autoimmune diseases, with a focus on elucidating the underlying molecular mechanisms and exploring the potential therapeutic implications.
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页数：20
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