The clinicopathologic patterns of Hodgkin's lymphoma in Lagos, Nigeria: A retrospective study

被引:0
作者
Awolola, Nicholas Awodele [1 ]
Akinde, Olakanmi Ralph [5 ]
Akinjo, Andrea Oludolapo [2 ]
Bamigboye, Babatunde Akinola [3 ]
Osunkalu, Vincent Oluseye [4 ]
Ajayi, Olugbende Obazee [2 ]
机构
[1] Univ Lagos, Coll Med, Dept Anat & Mol Pathol, Lagos, Nigeria
[2] Lagos Univ, Teaching Hosp, Dept Anat & Mol Pathol, Lagos, Nigeria
[3] Lagos Univ, Coll Med, Dept Ear Nose & Throat, Teaching Hosp, Lagos, Nigeria
[4] Lagos Univ, Dept Hematol & Blood Transfus, Coll Med, Teaching Hosp, Lagos, Nigeria
[5] Reg Lab, Histopathol Unit, Halfer Albatein, Saudi Arabia
关键词
Hodgkin; Lymphoma; pathology; stage; subtypes; variants; EPSTEIN-BARR-VIRUS; EUROPEAN TASK-FORCE; CLINICAL PRESENTATION; TREATMENT OUTCOMES; PROGNOSTIC-FACTORS; RISK-FACTORS; DISEASE; CLASSIFICATION; UPDATE; PREVALENCE;
D O I
10.4103/jcls.jcls_11_25
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background:Hodgkin's lymphoma is a malignant tumor of the lymph nodes that causes painless lymphadenopathy. Diagnosing it can be challenging, especially in the early stages, due to often nonspecific symptoms. This study addresses our center's increased Hodgkin's lymphoma (HL) incidence. Given the limited literature on this subject, we aim to enhance our understanding of HL's incidence and clinicopathological features in our environment.Methods:This retrospective study analyzed HL cases from 2010 to 2022 at Lagos University Teaching Hospital and two private laboratories. Clinical data were gathered from case files and laboratory requests, and both hematoxylin-eosin-stained sections and immunohistochemical slides were reviewed to classify the diseases morphologically.Results:A total of 50 HL cases were identified, primarily in the cervical region, with 5 and 4 cases in the inguinal and axillary regions, respectively. Among the 34 with clinical information, there were 35% in Ann Arbor stage I, 15% in stage II, none in stage III, and 9% in stage IV, while 41% had unspecified stages. The cohort comprised 40 males and 10 females, with a male-to-female ratio of 4:1. Ages ranged from 2 to 72 (mean 32.8), and most cases (68%) involved individuals in their third to fifth decades. Histologically, the breakdown was 44% nodular sclerosis, 30% mixed cellularity, 8% lymphocyte-rich, 4% lymphocyte-depleted, and four unclassified cases.Conclusions:HL is common at our center. It typically presents at a late stage, predominantly nodal, and is more frequent in young adult males. The nodular sclerosis (NS) subtype is the most common, and a bimodal peak is not observed. The increased frequency among young people and late presentations indicates a need for improved access to clinical and diagnostic services.
引用
收藏
页码:82 / 87
页数:6
相关论文
共 74 条
[51]  
2-1
[52]   Hodgkin lymphoma: Clinicopathologic features in Benin City, Nigeria and update on its biology and classification [J].
Olu-Eddo, A. N. ;
Omoti, C. E. .
NIGERIAN JOURNAL OF CLINICAL PRACTICE, 2011, 14 (04) :440-444
[53]   A Fifteen-year Review of Lymphomas in a Nigerian Tertiary Healthcare Centre [J].
Oluwasola, A. Olayiwola ;
Olaniyi, John A. ;
Otegbayo, Jesse A. ;
Ogun, Gabriel O. ;
Akingbola, Titi S. ;
Ukah, Cornelius O. ;
Akang, Effiong E. U. ;
Aken'Ova, Yetunde A. .
JOURNAL OF HEALTH POPULATION AND NUTRITION, 2011, 29 (04) :310-316
[54]   Adult lymphomas in Edo state, Niger Delta region of Nigeria - clinicopathological profile of 205 cases [J].
Omoti, CE ;
Halim, NKD .
CLINICAL AND LABORATORY HAEMATOLOGY, 2005, 27 (05) :302-306
[55]   The global health burden of infection -associated cancers in the year 2002 [J].
Parkin, Donald Maxwell .
INTERNATIONAL JOURNAL OF CANCER, 2006, 118 (12) :3030-3044
[56]   Hodgkin's lymphoma: the pathologist's viewpoint [J].
Pileri, SA ;
Ascani, S ;
Leoncini, L ;
Sabattini, E ;
Zinzani, PL ;
Piccaluga, PP ;
Pileri, A ;
Giunti, M ;
Falini, B ;
Bolis, GB ;
Stein, H .
JOURNAL OF CLINICAL PATHOLOGY, 2002, 55 (03) :162-176
[57]   Epidemiology of lymphomas [J].
Roman, Eve ;
Smith, Alexandra G. .
HISTOPATHOLOGY, 2011, 58 (01) :4-14
[58]  
ROSENBERG SA, 1966, CANCER RES, V26, P1225
[59]  
Said JW, 1997, SEMIN DIAGN PATHOL, V14, P48
[60]  
Shammo JM, 2003, ONCOLOGIC THERAPIES, SECOND EDITION, P269