Chemical Synthesis of Zinc Oxide Nanoparticles and Their Antimicrobial Potential Against Opportunistic Hospital Pathogens

被引：0

作者：

Allah, Osamah Raji Mal ^{[1
]}

El Arbi, Mehdi ^{[2
]}

机构：

[1] Minist Educ, Educ, Baghdad, Iraq

[2] Univ Sfax, Higher Inst Biotechnol, Sfax, Tunisia

来源：

JOURNAL OF NANOSTRUCTURES | 2025年 / 15卷 / 02期

关键词：

Acinetobacter baumannii; Antibiotic resistance; Ciprofloxacin; synergistic effect; Staphylococcus aureus; Zinc oxide nanoparticles; ZNO NANOPARTICLES; ANTIBACTERIAL ACTIVITY; COMBINATIONS; RESISTANCE; MECHANISM; TOXICITY;

D O I：

10.22052/JNS.2025.02.018

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Bacterial resistance to antibiotics is a growing global challenge. This study investigates the antimicrobial effects of zinc oxide nanoparticles (ZnO-NPs) on clinical strains of Acinetobacter baumannii and Staphylococcus aureus, focusing on their synergy with the antibiotic ciprofloxacin. ZnO-NPs were synthesized and characterized using XRD, FT-IR, and SEM techniques. Their antimicrobial activity was evaluated against both bacteria, and the minimum inhibitory concentration (MIC) was determined. The results demonstrated that ZnO-NPs effectively inhibited bacterial growth, with enhanced effects when combined with ciprofloxacin, particularly against A. baumannii. These findings suggest that ZnO-NPs could reduce antibiotic resistance and offer a promising approach to combating multidrug-resistant bacteria.

引用

页码：576 / 586

页数：11

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