A narrative review of serum biomarkers in progressive supranuclear palsy, corticobasal syndrome, and related disorders

被引：0

作者：

Giannakis, Alexandros ^{[1
]}

Konitsiotis, Spiridon ^{[2
]}

Sioka, Chrissa ^{[3
]}

机构：

[1] Univ Hosp Ioannina, Dept Neurol, 1 Stavrou Niarchou Av, Ioannina 45500, Greece

[2] Univ Ioannina, Fac Med, Sch Hlth Sci, Dept Neurol, Univ Campus, Ioannina 45500, Greece

[3] Univ Ioannina, Sch Hlth Sci, Fac Med, Dept Nucl Med, Univ Campus, Ioannina 45500, Greece

来源：

JOURNAL OF NEURAL TRANSMISSION | 2025年

关键词：

Progressive supranuclear palsy; Corticobasal syndrome; Biomarker; Neurodegenerative disease; Serum; FRONTOTEMPORAL LOBAR DEGENERATION; CLINICAL-FEATURES; DISEASE SEVERITY; ALPHA-SYNUCLEIN; DIAGNOSIS; PROGRANULIN; MUTATIONS; DEMENTIA; BLOOD;

D O I：

10.1007/s00702-025-02955-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This narrative review evaluates the diagnostic potential of serum biomarkers for progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), and related neurodegenerative diseases. Hyperphosphorylated tau species (p-tau), particularly p-tau217 and p-tau181, show promise in distinguishing PSP and CBS from other neurodegenerative diseases, though not from each other. While serum neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) exhibit limited individual utility, their combination with p-tau species enhances diagnostic accuracy. Other genome-associated, inflammatory, metabolic biomarkers, and neuropeptides yield interesting though inconsistent results. The majority of serum biomarkers yielded non-specific results in differentiating PSP and/or CBS from each other and from other related neurodegenerative diseases. Future large-scale, multi-center studies with autopsy confirmation in early-stage patients are essential for developing reliable biomarker panels. Direct comparative studies of PSP and CBS subtypes are also necessary for accurate phenotypic discrimination.

引用

页数：10

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