共 18 条
Transient Leukemia in an Adult Dog With Cutaneous T-Cell Lymphoma
被引:0
作者:

Moreira, Raquel
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机构:
Batt Labs, Coventry, England
Univ Edinburgh, Royal Dick Sch Vet Studies, Edinburgh, Scotland
Univ Edinburgh, Roslin Inst, Edinburgh, Scotland Batt Labs, Coventry, England

Ossowska, Malgorzata
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机构:
Blaise Referral Hosp, Birmingham, England Batt Labs, Coventry, England

Jornet-Rius, Oriol
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机构:
Batt Labs, Coventry, England
Zoetis Spain SLU, Madrid, Spain Batt Labs, Coventry, England

Santos, Marta
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机构:
Univ Porto, Sch Med & Biomed Sci, Cytol & Hematol Diagnost Serv, Lab Histol & Embryol,ICBAS, Porto, Portugal Batt Labs, Coventry, England

Cian, Francesco
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Batt Labs, Coventry, England Batt Labs, Coventry, England
机构:
[1] Batt Labs, Coventry, England
[2] Univ Edinburgh, Royal Dick Sch Vet Studies, Edinburgh, Scotland
[3] Univ Edinburgh, Roslin Inst, Edinburgh, Scotland
[4] Blaise Referral Hosp, Birmingham, England
[5] Zoetis Spain SLU, Madrid, Spain
[6] Univ Porto, Sch Med & Biomed Sci, Cytol & Hematol Diagnost Serv, Lab Histol & Embryol,ICBAS, Porto, Portugal
关键词:
canine;
flow cytometry;
immunocytochemistry;
immunohistochemistry;
marked leukocytosis;
non-epitheliotropic lymphoma;
BONE-MARROW;
D O I:
10.1111/vcp.70025
中图分类号:
S85 [动物医学(兽医学)];
学科分类号:
0906 ;
摘要:
A 5-year-old neutered female Beagle was presented with lethargy, vomiting, and reduced appetite. Physical examination revealed mild hyperthermia and a cutaneous thickness on the right thigh. Hematology showed marked leukocytosis and moderate thrombocytopenia, consisting of 80% of atypical circulating cells, initially suggesting acute undifferentiated leukemia. Two weeks later, repeated hematology revealed unremarkable results. Cytology of the skin lesion showed a round cell neoplasia with features similar to the atypical circulating cells. Following the development of multiple cutaneous nodules and recurrence of clinical signs, further diagnostics, including flow cytometry, histopathology, and immunohistochemistry (IHC) of the skin nodules, as well as PCR for antigen receptor rearrangement (PARR) and immunocytochemistry (ICC) from the initial blood smear, confirmed a neoplastic T-cell proliferation consistent with cutaneous T-cell lymphoma with a probable transient leukemic phase. Despite chemotherapy, remission was short-lived, and the patient relapsed, ultimately leading to euthanasia. This case highlights a rare instance of transient leukemia likely originating from a primary cutaneous T-cell lymphoma, emphasizing the need for comprehensive diagnostic workups, combining hematology, biochemistry, cytology, flow cytometry, and immunophenotyping to avoid misclassification in hematologic malignancies.
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