A transmurally heterogeneous model of the ventricular tissue and its application for simulation of Brugada Syndrome

被引：3

作者：

Biasi, NiccolO ^{[1
]}

Seghetti, Paolo ^{[2
,3
]}

Tognetti, Alessandro ^{[1
,4
]}

机构：

[1] Univ Pisa, Informat Engn Dept, Pisa, Italy

[2] Scuola Super Sant Anna, Inst Life Sci, Pisa, Italy

[3] CNR, Inst Clin Physiol, Pisa, Italy

[4] Univ Pisa, Res Ctr E Piaggio, Pisa, Italy

来源：

2022 44TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY, EMBC | 2022年

关键词：

ACTION-POTENTIALS; HEART; RESTITUTION; MYOCYTES; FIBROSIS; HUMANS; WAVE;

D O I：

10.1109/EMBC48229.2022.9871482

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

We present a transmurally heterogeneous phenomenological model of ventricular tissue that is designed to reproduce the most important features of action potential propagation of endocardial, midmyocardial, and epicardial tissue. Our model consists of only 3 variables and 20 parameters. Therefore, it is highly computational efficient and easy to fit to experimental data. We exploited our myocyte model to simulate action potential propagation in a 3D slab of cardiac tissue both in healthy conditions and in presence of Brugada syndrome. The results show that our model can accurately reproduce the transmural heterogeneity of the ventricular wall and the main characteristics of electrocardiographic pattern both in healthy and pathological conditions.

引用

页码：3951 / 3954

页数：4

共 23 条

[1] Brugada syndrome - Report of the second consensus conference - Endorsed by the Heart Rhythm Society and the European Heart Rhythm Association [J].