Cancer stem cells and tumor-associated macrophages: Interactions and therapeutic opportunities

被引：1

作者：

Yuan, Haitao ^{[1
]}

Qiu, Yun ^{[1
]}

Mei, Zijie ^{[1
]}

Liu, Jiaqing ^{[1
]}

Wang, Lingna ^{[1
]}

Zhang, Kaiqing ^{[1
]}

Liu, Huicong ^{[1
]}

Zhu, Fangfang ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai, Peoples R China

来源：

CANCER LETTERS | 2025年 / 624卷

基金：

中国国家自然科学基金;

关键词：

Cancer stem cells; Tumor-associated macrophages; Cancer stemness maintenance; Tumor microenvironment; Macrophage polarization; Chemokine/cytokine signaling; Exosomal miRNAs; CAR-Macrophage therapy; Immune checkpoint blockade; EPITHELIAL-MESENCHYMAL TRANSITION; NEGATIVE BREAST-CANCER; ACUTE MYELOID-LEUKEMIA; DUAL ROLE; PROMOTES; POLARIZATION; PROGRESSION; CARCINOMA; INDUCE; HETEROGENEITY;

D O I：

10.1016/j.canlet.2025.217737

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer stem cells (CSCs) depend on the tumor microenvironment (TME) to sustain their stem-like properties by recruiting monocytes and reprogramming them into tumor-associated macrophages (TAMs), which in turn promote tumor progression. This review explores CSC-TAM interactions, emphasizing how CSCs drive monocyte recruitment and TAM polarization. We discuss how TAMs enhance CSC stemness and niche maintenance through chemokines, cytokines, exosome-mediated miRNA transfer, direct interactions, and extracellular matrix (ECM) remodeling. Furthermore, we examine therapeutic strategies targeting TAMs, including inhibiting TAM differentiation, reprogramming TAM polarization, and leveraging immune checkpoint blockade and CAR-macrophage immunotherapy to improve cancer treatment outcomes.

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