Radical Cross-Coupling Reaction of NPIB Ester with Sodium Sulfinate Salts for the Synthesis of Sulfones

被引：0

作者：

Shah, Syed Anis Ali ^{[1
,2
]}

Liu, Bo-Xi ^{[1
,2
]}

Hasan, Muhammad ^{[1
,2
]}

Peng, Jing-Han ^{[1
,2
]}

Rao, WeiDong ^{[3
]}

Shen, Shu-Su ^{[4
]}

Sheng, DaoPeng ^{[5
,6
]}

Wang, Shun-Yi ^{[1
,2
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Soochow Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China

[3] Nanjing Forestry Univ, Coll Chem Engn, Key Lab Biomass Based Green Fuels & Chem, Nanjing 210037, Peoples R China

[4] Suzhou Univ Sci & Technol, Sch Environm Sci & Engn, Suzhou 215009, Peoples R China

[5] Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Jiangsu, Peoples R China

[6] Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher E, Suzhou 215123, Jiangsu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 26期

基金：

中国国家自然科学基金;

关键词：

REDOX-ACTIVE ESTERS; TERTIARY ALCOHOLS; SULFUR-DIOXIDE; QUATERNARY; CONSTRUCTION; N-(ACYLOXY)PHTHALIMIDES; SULFONYLATION; CENTERS;

D O I：

10.1021/acs.joc.5c01135

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report decarboxylative sulfonylation involving alpha-N-phthalimido-oxy isobutyrate (NPIB) as a radical precursor. We successfully developed different NPIBs from N-hydroxyphthalimide and alkyl butyl isobutyrate and subjected them to reactions with easily available sodium sulfinate salts as the sulfonylating source. A successful reaction was executed using Cu/4-CzIPN as dual catalysts under blue LED irradiation. The reaction featured functional group tolerance, compatibility with a wide range of sodium sulfinate salts, easily accessible starting materials, and moderate reaction conditions.

引用

页码：9200 / 9209

页数：10

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