Human Immune Responses to Epstein-Barr Virus Highlighted by Immunodeficiencies

被引：1

作者：

Latour, Sylvain ^{[1
,2
]}

机构：

[1] INSERM, UMR 1163, Lab Lymphocyte Activat & Susceptibil EBV Infect, Paris, France

[2] Univ Paris Cite, Inst Imagine, Paris, France

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2025年 / 43卷

关键词：

Epstein-Barr virus; inborn errors of immunity; CD8+T cells; infectious mononucleosis; lymphoproliferation; T-CELL KINASE; LINKED LYMPHOPROLIFERATIVE-DISEASE; NATURAL-KILLER-CELLS; SLAM FAMILY RECEPTORS; SYNTHASE; DEFICIENCY; INFECTED B-CELLS; EBV INFECTION; PROTEIN-DEFICIENCY; MAGT1; ANTIGEN AFFINITY;

D O I：

10.1146/annurev-immunol-082323-035455

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inborn errors of immunity (IEIs) represent unique in natura models that uncover key components of immunity in humans, in particular those that predispose to infections. Epstein-Barr virus (EBV) is one of the most common opportunistic infectious agents in humans and is responsible for several diseases, including infectious mononucleosis, nonmalignant and malignant lymphoproliferative disorders, hemophagocytic lymphohistiocytosis, and smooth muscle and epithelial tumors. For most individuals, EBV infection persists for life without pathological consequences. IEIs that do not predispose to EBV infection suggest that innate and humoral responses are not necessary or redundant for the immune response to EBV. IEIs associated with high susceptibility to EBV infection provide unequivocal genetic proof of the central role of CD8+ T cell responses in immunity to EBV. They also highlight the distinct steps and pathways required for, on the one hand, the effector cytotoxic functions of CD8+ T cells and, on the other hand, the expansion and maturation of cytotoxic CD8+ T cells.

引用

页码：723 / 749

页数：27

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