Mitochondrial Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

被引：2

作者：

Syed, Abu Mohammad ^{[1
]}

Karius, Alexander K. ^{[1
]}

Ma, Jin ^{[1
]}

Wang, Ping-yuan ^{[1
]}

Hwang, Paul M. ^{[1
]}

机构：

[1] NHLBI, Cardiovasc Branch, NIH, Bethesda, MD 20892 USA

来源：

PHYSIOLOGY | 2025年 / 40卷 / 04期

关键词：

ER stress; long COVID; ME/CFS; mitochondria; WASF3; MAGNETIC-RESONANCE-SPECTROSCOPY; ENDOPLASMIC-RETICULUM STRESS; SKELETAL-MUSCLE; SYNDROME ME/CFS; OPEN-LABEL; VENTRICULAR LACTATE; OXIDATIVE STRESS; METABOLISM; SYMPTOMS; GENE;

D O I：

10.1152/physiol.00056.2024

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder of unclear etiology that affects many individuals worldwide. One of its hallmark symptoms is prolonged fatigue following exertion, a feature also observed in long COVID, suggesting an underlying dysfunction in energy production in both conditions. Here, mitochondrial dysfunction and its potential pathogenetic role in these disorders are reviewed.

引用

页码：319 / 328

页数：10

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