Photoelectrochemical Iron-Nickel Synergistic Catalysis for C(sp3)-H and Dehydroxymethylative Acylation

被引：0

作者：

Zhou, Xiao ^{[1
]}

Zhong, Ping-Fu ^{[1
]}

Li, Zhuohua ^{[1
]}

Hu, Pengwei ^{[1
]}

Tu, Jialin ^{[1
]}

Yang, Chao ^{[1
]}

Guo, Lin ^{[1
]}

Xia, Wujiong ^{[1
,3
]}

Chen, Tingting ^{[2
]}

机构：

[1] Harbin Inst Technol Shenzhen, Sch Sci, State Key Lab Urban Water Resource & Environm, Shenzhen 518055, Peoples R China

[2] Dinghe Property Insurance Co, Shenzhen 518055, Peoples R China

[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

来源：

ORGANIC LETTERS | 2025年 / 27卷 / 26期

基金：

中国国家自然科学基金;

关键词：

H BOND FUNCTIONALIZATION; ORGANOMETALLIC REAGENTS; CHLORIDES;

D O I：

10.1021/acs.orglett.5c01884

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed an iron-nickel dual-catalytic system for efficient C(sp3)-H activation acylation of hydrocarbons and carboxylic acids under photoelectrochemical conditions. This system is based on ligand-to-metal charge transfer-mediated direct hydrogen atom transfer and is applicable to inert C(sp3)-H-containing compounds. It also enables dehydroxymethylative acylation of alcohols, both these two reactions demonstrating broad substrate scope and unconventional chemoselectivity. Gram-scale synthesis, flow chemistry, and mechanistic studies highlight its potential in sustainable C(acyl)-C bond formation.

引用

页码：6995 / 7000

页数：6

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