C19-Diterpenoid alkaloids from two plants of Aconitum sinoaxillare and Aconitum chasmanthum

被引：0

作者：

Tian, Ling-Feng ^{[1
,2
]}

Ye, Mei-Zhen ^{[1
]}

Li, Ting-Ting ^{[1
]}

Long, Qiao ^{[1
]}

Wang, Shu ^{[1
]}

Zhang, Min ^{[1
]}

Chen, Lin ^{[1
]}

Huang, Shuai ^{[1
,2
]}

Zhou, Xian-Li ^{[1
,2
]}

机构：

[1] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu 610031, Peoples R China

[2] Southwest Jiaotong Univ, Yibin Inst, Yibin 644000, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2025年

关键词：

Aconitum sinoaxillare W. T. Wang; Aconitum chasmanthum Stapf; C19-diterpenoid alkaloids; anti-inflammatory activity; cytotoxicity; analgesic activity; NORDITERPENOID ALKALOIDS; DITERPENOID ALKALOIDS; ROOTS; DEMETHYLATION; REVISION;

D O I：

10.1080/10286020.2025.2513492

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new compounds (1-5) were isolated from the whole plants of two species of Aconitum, including two aconitine-type C-19-diterpenoid alkaloids, sinoaxidines A (1) and B (2) and a franchetine-type C-19-diterpenoid alkaloid, sinoaxidine C (3) from Aconitum sinoaxillare W. T. Wang. Two aconitine-type C-19-diterpenoid alkaloids, chasmanthumines A (4) and B (5) from Aconitum chasmanthum Stapf, and forty known diterpenoid alkaloids were also isolated. The structures of all compounds were identified based on extensive IR, 1D, 2D NMR and HR-ESI-MS data analysis. Compound 6 exhibited potent inhibitory effects on the production of NO in RAW 264.7 cells with IC50 of 29.60 mu M respectively. [GRAPHICS]

引用

页数：14

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