Systemic Inflammatory Response Index in Cervical Pathologies (Human Papillomavirus and Cervical Neoplasia) and its Prognostic Value in Disease Prediction

Background: Cervical pathologies, from chronic cervicitis to cervical cancer, are a global public health issue. Inflammation is crucial to these disorders' development. The systemic inflammatory response may predict cancer and chronic inflammatory disease outcomes. Aim: This study aimed to determine the importance of systemic inflammatory response indicators in human papillomavirus (HPV) infection and cervical pathologies. Methods: In this retrospective analysis, pap smear, HPV, cervical biopsy, complete blood count (CBC) parameters, and systemic inflammatory response index (SIRI) of women who underwent gynecological examination were evaluated. Results: The study included 452 women. Mean platelet volume (MPV) was comparable in HPV other high-risk positive and negative women but lower in HPV Type-16/18 positive women (P < 0.001). Neutrophil/lymphocyte ratio, lymphocyte/monocyte ratio, eosinophil/lymphocyte ratio (ELR), platelet/lymphocyte ratio (PLR), systemic inflammatory index [SII (platelet x neutrophil/lymphocyte)], and SIRI (neutrophil x monocyte/lymphocyte) were also similar (P > 0.05). Low-grade intraepithelial lesion (LSIL) women have lower ages and pregnancies at pap smear (P < 0.05). The high-grade intraepithelial lesion (HSIL) group showed greater platelet (PLT) counts and decreased MPV than the other groups (P < 0.05). The LSIL group had considerably reduced eosinophil counts (P < 0.05). ELR was lower in the LSIL group (P = 0.004). PLR was the highest for HSIL and lowest for LSIL (P = 0.002). The SII was highest in the HSIL group and lowest in the LSIL group (P = 0.008). PLT and MPV were lower in the cervical biopsy-classified women than in the other cervical pathology and control groups (P = 0.03 and 0.001, respectively). Conclusion: We found a link between the mean PLT volume and HPV-related cervical disease.