Advances in the Synthesis and SAR of Pyrido[2,3-d]pyrimidine Scaffold

被引：0

作者：

Wei, Xiongpiao ^{[1
]}

Fan, Dang ^{[1
]}

Dong, Haifeng ^{[1
]}

Li, Min ^{[1
]}

Lv, Qiaoli ^{[2
]}

Zheng, Pengwu ^{[1
]}

Wang, Linxiao ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Jiangxi Prov Key Lab Drug Design & Evaluat, 605 Fenglin Rd, Nanchang 330013, Peoples R China

[2] Jiangxi Prov Canc Hosp, Jiangxi Canc Res Inst, 519 Beijing East Rd, Nanchang, Peoples R China

来源：

CURRENT PHARMACEUTICAL DESIGN | 2025年 / 31卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Pyrido[2,3-d]pyrimidine; one-pot multi-component reaction; antitumor; antibacterial; kinase inhibitors; pyridine derivatives; EFFICIENT SYNTHESIS; GREEN SYNTHESIS; DERIVATIVES; ANTICANCER; CATALYST; PYRIMIDINES; ANALOGS; FACILE; AGENTS;

D O I：

10.2174/0113816128338087241217072045

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pyrido[2,3-d]pyrimidine and its derivatives have garnered significant attention due to their potential biological and pharmacological activities. Research has demonstrated their significant potential for antitumor and antibacterial applications. Over the years, pyrido[2,3-d]pyrimidine derivatives have remained a research focus for scientists, with numerous synthetic methods and reaction conditions reported. This review comprehensively summarizes the fast, facile, and economical synthetic methods for pyrido[2,3-d]pyrimidine derivatives over the past years, which are categorized based on different synthetic precursors, and evaluates their antitumor and antibacterial activities, aiming to make them better serve the cause of human health.

引用

页码：1521 / 1536

页数：16

共 80 条

[31] Hexamethylenetetramine grafted layered double hydroxides as a novel and green heterogeneous ionic liquid catalyst for the synthesis of pyrido[2,3-d]pyrimidine derivatives [J].

Ghorbani-Vaghei, Ramin ;

Sarmast, Narges .

RESEARCH ON CHEMICAL INTERMEDIATES, 2018, 44 (07) :4483-4501

[32] Combination Therapies with CDK4/6 Inhibitors to Treat KRAS-Mutant Pancreatic Cancer [J].

Goodwin, Craig M. ;

Waters, Andrew M. ;

Klomp, Jennifer E. ;

Javaid, Sehrish ;

Bryant, Kirsten L. ;

Stalnecker, Clint A. ;

Drizyte-Miller, Kristina ;

Papke, Bjoern ;

Yang, Runying ;

Amparo, Amber M. ;

Ozkan-Dagliyan, Irem ;

Baldelli, Elisa ;

Calvert, Valerie ;

Pierobon, Mariaelena ;

Sorrentino, Jessica A. ;

Beelen, Andrew P. ;

Bublitz, Natalie ;

Luethen, Mareen ;

Wood, Kris C. ;

Petricoin III, Emanuel F. ;

Sers, Christine ;

McRee, Autumn J. ;

Cox, Adrienne D. ;

Der, Channing J. .

CANCER RESEARCH, 2023, 83 (01) :141-157

[33] Novel pyrazolo[3,4-b]pyridine derivatives: Synthesis, structure-activity relationship studies, and regulation of the AMPK/70S6K pathway [J].

Guo, Yating ;

Jiang, Xiaoding ;

Chang, Qi ;

Xiao, Zhihong ;

Chen, Zhuo ;

Jiang, Dejian ;

Hu, Gaoyun ;

Li, Qianbin .

ARCHIV DER PHARMAZIE, 2022, 355 (07)

[34] One-stage synthesis of condensed pyrimidines by reaction of substituted 3-(pyrimidin-5-yl)propanoic acids with ortho-diamines: Extension of limits [J].

Harutyunyan, A. A. .

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 52 (02) :235-239

[35] Development of fluorinated nicotinonitriles and fused candidates as antimicrobial, antibiofilm, and enzyme inhibitors [J].

Ibrahim, Mona H. ;

El Menofy, Nagwan G. ;

El Kiki, Shereen M. ;

Sherbiny, Farag F. ;

Ismail, Magda M. F. .

ARCHIV DER PHARMAZIE, 2022, 355 (07)

[36] DABCO-based ionic liquids: introduction of two metal-free catalysts for one-pot synthesis of 1,2,4-triazolo[4,3-a]pyrimidines and pyrido[2,3-d]pyrimidines [J].

Jamasbi, N. ;

Irankhah-Khanghah, M. ;

Shirini, F. ;

Tajik, H. ;

Langarudi, M. S. N. .

NEW JOURNAL OF CHEMISTRY, 2018, 42 (11) :9016-9027

[37] A Green Synthesis of 7-amino-5-(4-aroyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine-6-carbonitrile Derivatives by a One-pot Three-component Reaction [J].

Javahershenas, Ramin ;

Khalafy, Jabbar .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 54 (06) :3163-3168

[38] Novel 2-amino-4-aryl-6-pyridopyrimidines and N-alkyl derivatives: Synthesis, characterization and investigation of anticancer, antibacterial activities and DNA/BSA binding affinities [J].

Kahriman, Nuran ;

Peker, Kivanc ;

Serdaroglu, Vildan ;

Aydin, Ali ;

Usta, Asu ;

Fandakli, Seda ;

Yayli, Nurettin .

BIOORGANIC CHEMISTRY, 2020, 99

[39] Convenient synthesis of novel 4-substituted-amino-5-trifluoromethyl-2,7-disubstituted pyrido[2,3-d]pyrimidines and their antibacterial activity [J].

Kanth, S. Ravi ;

Reddy, G. Venkat ;

Kishore, K. Hara ;

Rao, P. Shanthan ;

Narsaiah, B. ;

Murthy, U. Surya Narayana .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2006, 41 (08) :1011-1016

[40] Efficient Synthesis and Reactions of New Functionally Substituted Pyrido[2,3-d]pyrimidine Candidates [J].

Khalifa, N. M. ;

Nossier, E. S. ;

Amr, A. E. .

RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2018, 88 (06) :1228-1231

← 1 2 3 4 5 6 7 8 →