Advances in the Synthesis and SAR of Pyrido[2,3-d]pyrimidine Scaffold

被引：0

作者：

Wei, Xiongpiao ^{[1
]}

Fan, Dang ^{[1
]}

Dong, Haifeng ^{[1
]}

Li, Min ^{[1
]}

Lv, Qiaoli ^{[2
]}

Zheng, Pengwu ^{[1
]}

Wang, Linxiao ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Pharm, Jiangxi Prov Key Lab Drug Design & Evaluat, 605 Fenglin Rd, Nanchang 330013, Peoples R China

[2] Jiangxi Prov Canc Hosp, Jiangxi Canc Res Inst, 519 Beijing East Rd, Nanchang, Peoples R China

来源：

CURRENT PHARMACEUTICAL DESIGN | 2025年 / 31卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Pyrido[2,3-d]pyrimidine; one-pot multi-component reaction; antitumor; antibacterial; kinase inhibitors; pyridine derivatives; EFFICIENT SYNTHESIS; GREEN SYNTHESIS; DERIVATIVES; ANTICANCER; CATALYST; PYRIMIDINES; ANALOGS; FACILE; AGENTS;

D O I：

10.2174/0113816128338087241217072045

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pyrido[2,3-d]pyrimidine and its derivatives have garnered significant attention due to their potential biological and pharmacological activities. Research has demonstrated their significant potential for antitumor and antibacterial applications. Over the years, pyrido[2,3-d]pyrimidine derivatives have remained a research focus for scientists, with numerous synthetic methods and reaction conditions reported. This review comprehensively summarizes the fast, facile, and economical synthetic methods for pyrido[2,3-d]pyrimidine derivatives over the past years, which are categorized based on different synthetic precursors, and evaluates their antitumor and antibacterial activities, aiming to make them better serve the cause of human health.

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收藏

页码：1521 / 1536

页数：16

相关论文

共 80 条

[1] Nanostructured Na2CaP2O7: A New and Efficient Catalyst for One-Pot Synthesis of 2-Amino-3-Cyanopyridine Derivatives and Evaluation of Their Antibacterial Activity [J].

Achagar, Redouane ;

Elmakssoudi, Abdelhakim ;

Thoume, Abderrahmane ;

Dakir, Mohamed ;

Elamrani, Abdelaziz ;

Zouheir, Yassine ;

Zahouily, Mohamed ;

Ait-Touchente, Zouhair ;

Jamaleddine, Jamal ;

Chehimi, Mohamed M. .

APPLIED SCIENCES-BASEL, 2022, 12 (11)

[2] Solvent-free microwave-assisted synthesis of novel pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidines with potential antifungal activity [J].

Acosta, Paola ;

Insuasty, Braulio ;

Ortiz, Alejandro ;

Abonia, Rodrigo ;

Sortino, Maximiliano ;

Zacchino, Susana A. ;

Quiroga, Jairo .

ARABIAN JOURNAL OF CHEMISTRY, 2016, 9 (03) :481-492

[3] Solid supported synthesis of structurally diverse dihydropyrido[2,3-d]pyrimidines using microwave irradiation [J].

Agarwal, A ;

Chauhan, PMS .

TETRAHEDRON LETTERS, 2005, 46 (08) :1345-1348

[4] Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors [J].

Al-Warhi, Tarfah ;

Al-Karmalawy, Ahmed A. ;

Elmaaty, Ayman Abo ;

Alshubramy, Maha A. ;

Abdel-Motaal, Marwa ;

Majrashi, Taghreed A. ;

Asem, Medhat ;

Nabil, Ahmed ;

Eldehna, Wagdy M. ;

Sharaky, Marwa .

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2023, 38 (01) :176-191

[5]

[Anonymous], 2018, J. Heterocycl. Chem, V55, P419, DOI [10.1002/jhet.3058, DOI 10.1002/JHET.3058]

[6] Identification of an antivirulence agent targeting the master regulator of virulence genes in Staphylococcus aureus [J].

Arya, Rekha ;

Kim, Truc ;

Youn, Joo Won ;

Bae, Taeok ;

Kim, Kyeong Kyu .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2023, 13

[7] Expedient multicomponent synthesis of a small library of some novel highly substituted pyrido[2,3-d]pyrimidine derivatives mediated and promoted by deep eutectic solvent and in vitro and quantum mechanical study of their antibacterial and antifungal activities [J].

Aryan, Reza ;

Beyzaei, Hamid ;

Nojavan, Masoomeh ;

Pirani, Fatemeh ;

Delarami, Hojat Samareh ;

Sanchooli, Mahmood .

MOLECULAR DIVERSITY, 2019, 23 (01) :93-105

[8] Synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines in the magnetized deionized water based on UV-visible study [J].

Bakherad, Mohammad ;

Bagherian, Ghadamali ;

Rezaeifard, Amin ;

Mosayebi, Fatemeh ;

Shokoohi, Behzad ;

Keivanloo, Ali .

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2021, 18 (04) :839-852

[9] Synthesis of new 3-cyanoacetamide pyrrole and 3-acetonitrile pyrrole derivatives [J].

Bayat, Mohammad ;

Nasri, Shima ;

Notash, Behrouz .

TETRAHEDRON, 2017, 73 (11) :1522-1527

[10] Synthesis and Evaluation of Pyrido[2,3-d]pyrimidine and 1,8-Naphthyridine Derivatives as Potential Antitumor Agents [J].

Behalo, Mohamed S. ;

Mele, Giuseppe .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 54 (01) :295-300

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