Long-Term Outcome of Paediatric Crohn's Disease Patients With Deep Ulcerations at Diagnosis

被引：2

作者：

Ronconi, Monica S. ^{[1
]}

Neuraz, Antoine ^{[2
]}

Payen, Elise ^{[1
]}

Nader, Elie Abi ^{[1
]}

Lambe, Cecile ^{[1
]}

Campeotto, Florence ^{[1
,3
]}

Talbotec, Cecile ^{[1
]}

Ruemmele, Frank M. ^{[1
,4
]}

Pigneur, Benedicte ^{[1
,3
]}

机构：

[1] Univ Paris Cite, Hop Necker Enfants Malad, AP HP, Ctr Reference Malad Rares Digest MARDI,Serv Gastro, Paris, France

[2] AP HP, Imagine Inst, Dept Biostat, Paris, France

[3] Univ Paris Cite, Fac Pharm Paris, INSERM, UMR S 1139, Paris, France

[4] Inst Imagine, INSERM, Immun Intestinale, UMR 1163, Paris, France

来源：

ACTA PAEDIATRICA | 2025年

关键词：

children; endoscopy; IBD; prognostic factor; ulcerations; INFLAMMATORY-BOWEL-DISEASE; NATURAL-HISTORY; FOLLOW-UP; TOP-DOWN; STEP-UP; MANAGEMENT; CHILDREN; MULTICENTER; THERAPY;

D O I：

10.1111/apa.70115

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

AimPresence of deep ulcerations (DU) at diagnosis seems to be predictive of a more severe phenotype in adult Crohn's disease (CD). The aim of our study was to investigate if the presence of DU at diagnosis was associated with a more severe disease course over time in children.MethodsIn this monocentric retrospective study, we analysed data from paediatric patients with a new diagnosis of CD from 2009 to 2017. Clinical, laboratory data, treatments and complications were recorded for each patient at diagnosis and at 1, 3 and 5 years of follow-up. Patients were compared according to the presence or absence of DU on colonoscopy.ResultsAmong the 116 patients included in the study, 52 patients had DU at diagnosis. Comparison showed an increased risk for patients with DU to develop abdominal abscesses (p = 0.045) and to experience more relapses (p = 0.013) at 1 year. At 3 and 5 years, there was no longer any difference between groups. The time from diagnosis to first anti-TNF alpha was shorter in DU patients.ConclusionThe presence of DU at diagnosis is associated with more complications during the first year of follow-up but not after, due to a more active therapeutic management.

引用

页数：8

共 24 条

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