MicroRNAs' Impact on Heart Diseases

被引：0

作者：

Cordeiro, Marco Antonio ^{[1
]}

de Carvalho, Ana Elisa T. S. ^{[1
]}

Spadari, Regina Celia ^{[1
]}

机构：

[1] Fed Univ Sao Paulo UNIFESP, Hlth & Soc Inst, Dept Biosci, Lab Stress Biol, Campus Baixada Santista, BR-11020015 Santos, SP, Brazil

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 12期

基金：

巴西圣保罗研究基金会;

关键词：

cardiovascular diseases (CVDs); microRNAs (miRNAs); heart; epigenetics mechanisms; CIRCULATING MICRORNAS; NONCODING RNAS; CARDIOVASCULAR-DISEASE; CARDIAC-HYPERTROPHY; GENE-EXPRESSION; MESSENGER-RNAS; BIOGENESIS; MECHANISM; MIRNAS; CONDUCTION;

D O I：

10.3390/ijms26125566

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cardiovascular diseases (CVDs) are the most prevalent cause of global mortality, highlighting the importance of understanding their molecular bases. Recently, small non-coding RNAs (miRNAS) were shown to affect messenger RNA (mRNA) stability, either by inhibiting translation or by causing degradation through base pairing with mRNAs, being negative regulators of protein translation. Moreover, miRNAs modulate many signaling pathways and cellular processes, including cell-to-cell communication. In the cardiovascular system, miRNAs control functions in cardiomyocytes, endothelial cells, smooth muscle cells, and fibroblasts. Because miRNA expression was detected in the blood of patients with various cardiovascular diseases, they are considered attractive candidates for noninvasive biomarkers. This study reviews the literature on the role played by miRNAs in heart development and diseases. The findings suggest that miRNA regulation may offer new perspectives for therapeutic interventions in heart diseases.

引用

页数：17

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