Renal cell carcinoma associated with XP11.2 translocation: A case report and literature review

被引：0

作者：

Alsaikhan, Bader ^{[1
,2
,3
]}

AlHussayen, Saud ^{[1
]}

Almajed, Ebtesam ^{[4
]}

Alghuraibi, Abdullah ^{[1
]}

Almodeth, Khaled ^{[5
]}

Al Oudah, Noura ^{[6
]}

Alabdulsalam, Abdulrahman K. ^{[6
]}

机构：

[1] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Med, Riyadh, Saudi Arabia

[2] Minist Natl Guard Hlth Affairs, Dept Surg, Div Urol, Riyadh, Saudi Arabia

[3] King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia

[4] Princess Nourah Bint Abdulrahman Univ, Coll Med, Dept Clin Sci, Riyadh, Saudi Arabia

[5] Imam Mohammad Ibn Saud Islamic Univ, Coll Med, Riyadh, Saudi Arabia

[6] Minist Natl Guard Hlth Affairs, Dept Pathol & Lab Med, Riyadh, Saudi Arabia

来源：

UROLOGY CASE REPORTS | 2025年 / 61卷

关键词：

Xp11.2; translocation; Renal cell carcinoma; Transcription factor E3 gene fusion; Case report; FEATURES; SERIES;

D O I：

10.1016/j.eucr.2025.103057

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Renal cell carcinoma (RCC) associated with XP11.2 translocation is an exceedingly rare subtype of RCC. A 27-year-old female presented with a 6.7cm mass and underwent a robotic-assisted left radical nephrectomy with uneventful recovery. Pathology revealed clear cell carcinoma with papillary and glandular features, positive for Melan-A, consistent with MIT family translocation renal cell carcinoma. The infrequent occurrence and its nonspecific clinical and radiological presentation results in a considerable diagnostic challenge. Given the potentially more aggressive behavior of Xp11.2 translocation RCC, particularly in adults, a thorough understanding of the tumor's genetic profile is critical for optimizing patient management and improving outcomes.

引用

页数：4

共 19 条

[1] Preoperative neutrophil-to-lymphocyte ratio predicts the surgical outcome of Xp11.2 translocation/TFE3 renal cell carcinoma patients [J].

Agizamhan, Sezim ;

Qu, Feng ;

Liu, Ning ;

Sun, Jing ;

Xu, Wei ;

Zhang, Lihua ;

Guo, Hongqian ;

Gan, Weidong .

BMC UROLOGY, 2018, 18

[2] Clinicopathologic Characteristics and Prognosis of Xp11.2 Translocation Renal Cell Carcinoma: Multicenter, Propensity Score Matching Analysis [J].

Choo, Min Soo ;

Jeong, Chang Wook ;

Song, Cheryn ;

Jeon, Hwang Gyun ;

Seo, Seong Il ;

Hong, Sung Kyu ;

Byun, Seok-Soo ;

Chung, Jin Soo ;

Hong, Sung-Hoo ;

Hwang, Eu Chang ;

Kim, Hyeon Hoe ;

Kwak, Cheol .

CLINICAL GENITOURINARY CANCER, 2017, 15 (05) :E819-E825

[3] A Case of Adult Metastatic Xp11 Translocation Renal Cell Carcinoma Treated Successfully With Sunitinib [J].

Choueiri, Toni K. ;

Mosquera, Juan-Miguel ;

Hirsch, Michelle S. .

CLINICAL GENITOURINARY CANCER, 2009, 7 (03) :E93-E94

[4] Pediatric renal cell carcinoma: Single institution 25-year case series and initial experience with partial nephrectomy [J].

Cook, A ;

Lorenzo, AJ ;

Salle, JLP ;

Bakhshi, M ;

Cartwright, LM ;

Bagi, D ;

Farhat, W ;

Khoury, A .

JOURNAL OF UROLOGY, 2006, 175 (04) :1456-1460

[5] Xp11.2 Translocation Renal Cell Carcinoma: Clinical Characteristics and Potential Prognostic Predictors [J].

Dong, Jie ;

Xu, Weifeng ;

Ji, Zhigang ;

Pan, Boju .

DISEASE MARKERS, 2021, 2021

[6] Management of translocation carcinomas of the kidney [J].

Ged, Yasser ;

Feinaj, Ardit ;

Baraban, Ezra ;

Singla, Nirmish .

TRANSLATIONAL CANCER RESEARCH, 2024, 13 (11) :6438-6447

[7] Translocation renal cell carcinoma - Lack of negative impact due to lymph node spread [J].

Geller, James I. ;

Argani, Pedram ;

Adeniran, Adebowale ;

Hampton, Edith ;

De Marzo, Angelo ;

Hicks, Jessica ;

Collins, Margaret H. .

CANCER, 2008, 112 (07) :1607-1616

[8] Bilateral Xp11.2 translocation renal cell carcinoma: a case report [J].

Karashima, Takashi ;

Kuno, Takahira ;

Kuroda, Naoto ;

Satake, Hirofumi ;

Fukata, Satoshi ;

Chikazawa, Masakazu ;

Kawada, Chiaki ;

Yamasaki, Ichiro ;

Shuin, Taro ;

Hiroi, Makoto ;

Inoue, Keiji .

BMC UROLOGY, 2018, 18

[9] Xp 11.2 translocation renal carcinoma in young adults; recently classified distinct subtype [J].

Kmetec, Andrej ;

Jeruc, Jera .

RADIOLOGY AND ONCOLOGY, 2014, 48 (02) :197-202

[10] An aggressive course of Xp11 translocation renal cell carcinoma in a 28-year-old man [J].

Koie, Takuya ;

Yoneyama, Takahiro ;

Hashimoto, Yasuhiro ;

Kamimura, Noritaka ;

Kusumi, Tomomi ;

Kijima, Hiroshi ;

Ohyama, Chikara .

INTERNATIONAL JOURNAL OF UROLOGY, 2009, 16 (03) :333-335

← 1 2 →