Pathophysiological Differences and Differential Diagnosis of Autoimmune and Drug-Induced Hepatitis

被引：0

作者：

Zeni, Nicola ^{[1
]}

Cristofani, Alessandro ^{[1
]}

Piano, Salvatore Silvio ^{[1
]}

Bolognesi, Massimo ^{[1
]}

Romano, Antonietta ^{[1
,2
]}

机构：

[1] Univ Padua, Dept Med, Unit Internal Med & Hepatol, I-35128 Padua, Italy

[2] Univ Padua, Dept Med, Via Giustiniani 2, I-35128 Padua, Italy

来源：

LIVERS | 2025年 / 5卷 / 02期

关键词：

immune-mediated liver injury; causality assessment; serological markers; histopathological analysis; INDUCED LIVER-INJURY; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; T-CELLS; IDIOPATHIC AUTOIMMUNE; LARGE COHORT; MECHANISMS; TOLERANCE; POPULATION; CRITERIA; OUTCOMES;

D O I：

10.3390/livers5020022

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Autoimmune hepatitis (AIH) and drug-induced liver injury (DILI) are major causes of liver inflammation with distinct pathophysiology but overlapping clinical features. Among acute cases, DILI is a key differential diagnosis for AIH, especially when drug history is unclear or the injury is non-dose-dependent. Mechanisms of DILI include direct toxicity, metabolic idiosyncrasies, and immune-mediated responses that can mimic AIH. Moreover, certain drugs can induce AIH-like syndromes, further complicating the diagnosis. While causality assessment tools aid initial evaluations, liver biopsy remains valuable for distinguishing AIH from DILI; given these complexities, hepatologist consultation is often essential to ensure appropriate diagnosis and treatment management.

引用

页数：19

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