Immunosenescence Profile Is Associated With Increased Susceptibility to Severe COVID-19

被引：0

作者：

Ventura, Lucas Haniel A. ^{[1
]}

Torres, Licia ^{[1
]}

Camatta, Giovanna Caliman ^{[1
]}

Zamame, Jofer ^{[2
]}

Coelho, Monique Macedo ^{[1
]}

Ramalho-Pinto, Cecilia Horta ^{[1
]}

Gervazio, Joao ^{[1
]}

Caixeta, Felipe ^{[1
]}

Nascimento, Leandro ^{[1
]}

Oliveira, Mariana Almeida ^{[1
]}

Martins, Vinicius Dantas ^{[1
]}

Oliveira, Marcos Felipe ^{[1
]}

Costa, Murilo Soares ^{[3
,4
]}

Sato, Hugo Itaru ^{[1
]}

Guimaraes, Henrique Cerqueira ^{[5
]}

Barbuto, Rafael Calvao ^{[5
]}

Veiga, Ana Paula Rocha ^{[6
]}

Ataide, Najara ^{[6
]}

Caetano, Gabriela Prandi ^{[6
]}

Rangon, Sarah ^{[6
]}

Junior, Mauro Lucio O. ^{[7
]}

Fortes, Fernanda Calvo ^{[1
]}

Zuccherato, Luciana ^{[1
]}

Speziali, Elaine ^{[8
,9
]}

Martins-Filho, Olindo Assis ^{[8
]}

Coelho, Veronica ^{[10
]}

Avritchir, Roberto ^{[11
]}

Souza, Rafael ^{[6
]}

Ayupe, Marina ^{[2
]}

Loureiro, Caio ^{[2
]}

Passos, Maria Eduarda

Neves, Ana Clara Mota

Leite, Pauline

Teixeira, Santuza Maria Ribeiro ^{[1
]}

Tupinambas, Unai ^{[3
,4
]}

Felicori, Liza Figueiredo ^{[1
]}

Silveira-Nunes, Gabriela

Maioli, Tatiani Uceli ^{[1
,12
]}

Fonseca, Denise Morais ^{[2
]}

Teixeira-Carvalho, Andrea ^{[8
]}

Faria, Ana Maria Caetano ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Bioquim & Imunol, Inst Ciencias Biol, Belo Horizonte, Brazil

[2] Univ Sao Paulo, Dept Imunol, Inst Ciencias Biomed, Sao Paulo, Brazil

[3] Univ Fed Minas Gerais, Dept Clin Med, Fac Med, Belo Horizonte, Brazil

[4] Univ Fed Minas Gerais, Posgrad Infectol & Doencas Tropicais, Belo Horizonte, Brazil

[5] Hosp Risoleta Tolentino Neves, Belo Horizonte, MG, Brazil

[6] Inst Infectol Emilio Ribas, Sao Paulo, Brazil

[7] Hosp UNIMED, Governador Valadares, Brazil

[8] Fundacao Oswaldo Cruz, Inst Rene Rachou, Belo Horizonte, Brazil

[9] Univ Edson Antonio Velano, Fundacao Ensino & Tecnol Alfenas, Belo Horizonte, Brazil

[10] Univ Sao Paulo, Inst Coracao, Sao Paulo, Brazil

[11] St Casa Misericordia Sao Paulo, Sao Paulo, Brazil

[12] Univ Fed Minas Gerais, Dept Nutr, Escola Enfermagem, Belo Horizonte, MG, Brazil

来源：

AGING CELL | 2025年 / 24卷 / 07期

关键词：

COVID-19; epigenetic clock; immunoglobulin repertoire; immunosenescence; inflammaging; T cell exhaustion; T cell senescence; CD8(+) T-CELLS; AGE; REPERTOIRE; SENESCENCE; INFLUENZA;

D O I：

10.1111/acel.70077

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this study, we tested the hypothesis that the immunosenescence profile could account for the disproportional susceptibility of the elderly to severe forms of COVID-19. The immunological profiles of volunteers residing in endemic and non-endemic areas for chronic infectious diseases were analyzed at the early stage of SARS-CoV-2 infection. A unique signature of inflammatory plasma mediators was identified in COVID-19 volunteers when compared to individuals with other flu-like syndromes. COVID-19 severity correlated with high levels of inflammatory mediators; among them, CXCL9, a serum marker of aging. Patients who progressed to hospitalization displayed high frequencies of CD8+ and CD4+ T cells expressing exhaustion and senescence markers and showed reduced and more mature B cell repertoires, which are typical of senescence. They also had an acceleration of epigenetic age measured by DNA methylation. Therefore, severe COVID-19 correlated with phenotypic, functional, and epigenetic features of accelerated immunosenescence at the onset of infection.

引用

页数：22

共 71 条

[1]

[Anonymous], 1995, WHO EXPERT COMMITTEE

[2] Critically Ill Coronavirus Disease 2019 Patients Exhibit Hyperactive Cytokine Responses Associated With Effector Exhausted Senescent T Cells in Acute Infection [J].

Arcanjo, Angelica ;

Pinto, Kamila Guimaraes ;

Logullo, Jorgete ;

Correa Leite, Paulo Emilio ;

Barreto Menezes, Camilla Cristie ;

Freire-de-Lima, Leonardo ;

Diniz-Lima, Israel ;

Decote-Ricardo, Debora ;

Rodrigues-da-Silva, Rodrigo Nunes ;

Freire-de-Lima, Celio Geraldo ;

Filardy, Alessandra Almeida ;

Lima-Junior, Josue da Costa ;

Bertho, Alvaro Luiz ;

De Luca, Paula Mello ;

Granjeiro, Jose Mauro ;

Coutinho Barroso, Shana Priscila ;

Conceicao-Silva, Fatima ;

Savino, Wilson ;

Morrot, Alexandre .

JOURNAL OF INFECTIOUS DISEASES, 2021, 224 (10) :1672-1683

[3] Telomeres and COVID-19 [J].

Aviv, Abraham .

FASEB JOURNAL, 2020, 34 (06) :7247-7252

[4] Inflammaging in Endemic Areas for Infectious Diseases [J].

Batista, Marina Andrade ;

Calvo-Fortes, Fernanda ;

Silveira-Nunes, Gabriela ;

Camatta, Giovanna Caliman ;

Speziali, Elaine ;

Turroni, Silvia ;

Teixeira-Carvalho, Andrea ;

Martins-Filho, Olindo A. ;

Neretti, Nicola ;

Maioli, Tatiani Uceli ;

Santos, Rodrigo Ribeiro ;

Brigidi, Patrizia ;

Franceschi, Claudio ;

Faria, Ana Maria Caetano .

FRONTIERS IN IMMUNOLOGY, 2020, 11

[5] Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes [J].

Bonafe, Massimiliano ;

Prattichizzo, Francesco ;

Giuliani, Angelica ;

Storci, Gianluca ;

Sabbatinelli, Jacopo ;

Olivieri, Fabiola .

CYTOKINE & GROWTH FACTOR REVIEWS, 2020, 53 :33-37

[6] Variation Rhythms of Lymphocyte Subsets during Healthy Aging [J].

Caetano Faria, Ana Maria ;

Monteiro de Moraes, Sara ;

Helene Ferreira de Freitas, Ludmila ;

Speciali, Elaine ;

Figueiredo Soares, Taciana ;

Pretti Figueiredo-Neves, Suzane ;

Marquete Vitelli-Avelar, Danielle ;

Angela Martins, Marina ;

Bastos Dias Barbosa, Katia Valeria ;

Soares, Eric Basseti ;

Sathler-Avelar, Renato ;

Peruhype-Magalhaes, Vanessa ;

Cardoso, Glenda Meira ;

Comin, Fabiano ;

Teixeira, Rosangela ;

Eloi-Santos, Silvana Maria ;

Magalhaes Queiroz, Dulciene Maria ;

Correa-Oliveira, Rodrigo ;

Bauer, Moises Evandro ;

Teixeira-Carvalho, Andrea ;

Martins-Filho, Olindo Assis .

NEUROIMMUNOMODULATION, 2008, 15 (4-6) :365-379

[7] The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11 Are Upregulated Following SARS-CoV-2 Infection in an AKT-Dependent Manner [J].

Callahan, Victoria ;

Hawks, Seth ;

Crawford, Matthew A. ;

Lehman, Caitlin W. ;

Morrison, Holly A. ;

Ivester, Hannah M. ;

Akhrymuk, Ivan ;

Boghdeh, Niloufar ;

Flor, Rafaela ;

Finkielstein, Carla, V ;

Allen, Irving Coy ;

Weger-Lucarelli, James ;

Duggal, Nisha ;

Hughes, Molly A. ;

Kehn-Hall, Kylene .

VIRUSES-BASEL, 2021, 13 (06)

[8] Senolytics reduce coronavirus-related mortality in old mice [J].

Camell, Christina D. ;

Yousefzadeh, Matthew J. ;

Zhu, Yi ;

Prata, Larissa G. P. Langhi ;

Huggins, Matthew A. ;

Pierson, Mark ;

Zhang, Lei ;

O'Kelly, Ryan D. ;

Pirtskhalava, Tamar ;

Xun, Pengcheng ;

Ejima, Keisuke ;

Xue, Ailing ;

Tripathi, Utkarsh ;

Espindola-Netto, Jair Machado ;

Giorgadze, Nino ;

Atkinson, Elizabeth J. ;

Inman, Christina L. ;

Johnson, Kurt O. ;

Cholensky, Stephanie H. ;

Carlson, Timothy W. ;

LeBrasseur, Nathan K. ;

Khosla, Sundeep ;

O'Sullivan, M. Gerard ;

Allison, David B. ;

Jameson, Stephen C. ;

Meves, Alexander ;

Li, Ming ;

Prakash, Y. S. ;

Chiarella, Sergio E. ;

Hamilton, Sara E. ;

Tchkonia, Tamara ;

Niedernhofer, Laura J. ;

Kirkland, James L. ;

Robbins, Paul D. .

SCIENCE, 2021, 373 (6552)

[9] Accelerated biological aging in COVID-19 patients [J].

Cao, Xue ;

Li, Wenjuan ;

Wang, Ting ;

Ran, Dongzhi ;

Davalos, Veronica ;

Planas-Serra, Laura ;

Pujol, Aurora ;

Esteller, Manel ;

Wang, Xiaolin ;

Yu, Huichuan .

NATURE COMMUNICATIONS, 2022, 13 (01)

[10] Lessons from Sicilian centenarians for anti-ageing medicine. The Oxi-infllammatory status [J].

Caruso, Calogero ;

Accardi, Giulia ;

Aiello, Anna ;

Calabro, Anna ;

Ligotti, Mattia Emanuela ;

Candore, Giuseppina .

TRANSLATIONAL MEDICINE AT UNISA, 2022, 24 (02)

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