Microbiota-centered interventions to boost immune checkpoint blockade therapies

被引：3

作者：

Almonte, Andrew A. ^{[1
,2
]}

Thomas, Simon ^{[1
,2
,3
]}

Zitvogel, Laurence ^{[1
,2
,3
,4
]}

机构：

[1] Gustave Roussy, Clin Biome, Canc Campus, Villejuif, France

[2] INSERM, U1015, Equipe Labellisee Ligue Natl Canc, Villejuif, France

[3] Univ Paris Saclay, Le Kremlin Bicetre, France

[4] Ctr Clin Invest Biotherapies Canc BIOTHERIS 1428, Villejuif, France

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2025年 / 222卷 / 07期

关键词：

FECAL MICROBIOTA; GUT MICROBIOME; CLOSTRIDIUM-BUTYRICUM; CANCER-IMMUNOTHERAPY; ANTITUMOR IMMUNITY; ADVERSE EVENTS; TRANSPLANTATION; EFFICACY; COMBINATION; RESISTANCE;

D O I：

10.1084/jem.20250378

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune checkpoint blockade therapies have markedly advanced cancer treatment by invigorating antitumor immunity and extending patient survival. However, therapeutic resistance and immune-related toxicities remain major concerns. Emerging evidence indicates that microbial dysbiosis diminishes therapeutic response rates, while a diverse gut ecology and key beneficial taxa correlate with improved treatment outcomes. Therefore, there is a growing understanding that manipulating the gut microbiota could boost therapy efficacy. This review examines burgeoning methods that target the gut microbiome to optimize therapy and innovative diagnostic tools to detect dysbiosis, and highlights challenges that remain to be addressed in the field.

引用

页数：16

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