Study on encapsulation and properties vitamin A acetate/cyclodextrin

被引：0

作者：

Wang, Xinyue ^{[1
]}

Xu, Xiaohu ^{[1
]}

Zhang, Haiyang ^{[1
]}

Yin, Chunhua ^{[1
]}

机构：

[1] School of Chemical and Biological Engineering, University of Science and Technology Beijing, Beijing

来源：

Huagong Xuebao/CIESC Journal | 2024年 / 75卷

关键词：

cyclodextrin; molecular simulation; solubility; stability; vitamin A acetate;

D O I：

10.11949/0438-1157.20240291

中图分类号：

学科分类号：

摘要：

The inclusion complexes of VAA with β-cyclodextrin (β-CD) and its derivatives hydroxypropyl βcyclodextrin (HP-β-CD) and sulfobutyl ether β-cyclodextrin (SBE-β-CD) were prepared by freeze-drying method, and the inclusion complexes were characterized by Fourier infrared spectroscopy (FT-IR), nuclear magnetic resonance hydrogen spectroscopy (1H NMR), and scanning electron microscope (SEM), and phase solubility, thermal stability, solubility and molecular binding mode were analyzed. The results of the phase solubility experiments showed that all the three cyclodextrins formed an inclusion ratio of 1∶1 with VAA, among which HP-β-CD had the highest stability constant and was more effective than the other two cyclodextrins in the inclusion of VAA. The experimental results of thermal stability and solubility change tests showed that the thermal stability and water solubility of the three inclusion compounds were substantially improved compared with free VAA, with VAA/HP-β -CD being the best, with the heat loss rate decreasing from 52.6% to 5.2%; and the water solubility increasing from 1.9×10-4 to 100 g/100 g. The results of the molecular docking showed that HP- β-CD enlarged the β-CD cavity length so that VAA was completely encapsulated and formed intermolecular hydrogen bonding with VAA, and the inclusion complex formed with VAA had minimal binding energy. The above results indicate that HP-β-CD is an excellent encapsulation carrier for VAA and can effectively improve the application performance of VAA. © 2024 Materials China. All rights reserved.

引用

页码：321 / 328

页数：7

共 30 条

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