Immunoglobulin G4-related Autoimmune Pancreatitis and Hypopituitarism Following Immune Checkpoint Inhibitor Therapy

被引：3

作者：

Inoue, Saori ^{[1
]}

Tsunoda, Yukiko ^{[2
]}

Yamamoto, Kana

Okamoto, Hideki ^{[1
,3
]}

机构：

[1] Meitetsu Hosp, Dept Endocrinol & Metab, Nagoya, Japan

[2] Meitetsu Hosp, Dept Urol, Nagoya, Japan

[3] Meitetsu Hosp, Dept Gastroenterol, Nagoya, Japan

来源：

INTERNAL MEDICINE | 2025年 / 64卷 / 02期

关键词：

immunoglobulin G4-related disease; autoimmune pancreatitis; hypopituitarism; immune checkpoint inhibitor; immune-related adverse events;

D O I：

10.2169/internalmedicine.3591-24

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 70-year-old man underwent nephrectomy for renal cell carcinoma followed by 3 cycles of pembrolizumab as adjuvant chemotherapy. Three months later, he complained of appetite loss. He was diagnosed with secondary adrenal insufficiency and pancreatic tumor. Amylase and immunoglobulin G (IgG) 4 levels were normal. The differential diagnosis poses challenges in distinguishing pancreatic cancer, renal cell carcinoma metastasis, and autoimmune pancreatitis, necessitating tumor resection surgery. A histological examination revealed IgG4-related sclerosing pancreatitis. Postoperatively, there was no recurrence of pancreatitis. It is essential to consider the potential development of IgG4-related diseases after the administration of immune checkpoint inhibitors.

引用

页码：209 / 215

页数：7

共 17 条

[1] Immunoglobulin G4 associated autoimmune cholangitis and pancreatitis following the administration of nivolumab: A case report [J].

Agrawal, Rohit ;

Guzman, Grace ;

Karimi, Saman ;

Giulianotti, Pier Cristoforo ;

Lora, Alfredo Jose Mena ;

Jain, Shikha ;

Khan, Meshaal ;

Boulay, Brian R. ;

Chen, Yolande .

WORLD JOURNAL OF CLINICAL CASES, 2022, 10 (20) :7124-7129

[2] Differences between immunotherapy-induced and primary hypophysitis-a multicenter retrospective study [J].

Amereller, Felix ;

Deutschbein, Timo ;

Joshi, Mamta ;

Schopohl, Jochen ;

Schilbach, Katharina ;

Detomas, Mario ;

Duffy, Leo ;

Carroll, Paul ;

Papa, Sophie ;

Stoermann, Sylvere .

PITUITARY, 2022, 25 (01) :152-158

[3]

Champion Benjamin, 2023, Pathology, V55, P133, DOI 10.1016/j.pathol.2022.04.010

[4] Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma [J].

Choueiri, T. K. ;

Tomczak, P. ;

Park, S. H. ;

Venugopal, B. ;

Ferguson, T. ;

Chang, Y. -H. ;

Hajek, J. ;

Symeonides, S. N. ;

Lee, J. L. ;

Sarwar, N. ;

Thiery-Vuillemin, A. ;

Gross-Goupil, M. ;

Mahave, M. ;

Haas, N. B. ;

Sawrycki, P. ;

Gurney, H. ;

Chevreau, C. ;

Melichar, B. ;

Kopyltsov, E. ;

Alva, A. ;

Burke, J. M. ;

Doshi, G. ;

Topart, D. ;

Oudard, S. ;

Hammers, H. ;

Kitamura, H. ;

Bedke, J. ;

Perini, R. F. ;

Zhang, P. ;

Imai, K. ;

Willemann-Rogerio, J. ;

Quinn, D. I. ;

Powles, T. .

NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (08) :683-694

[5] High serum IgG4 concentrations in patients with sclerosing pancreatitis. [J].

Hamano, H ;

Kawa, S ;

Horiuchi, A ;

Unno, H ;

Furuya, N ;

Akamatsu, T ;

Fukushima, M ;

Nikaido, T ;

Nakayama, K ;

Usuda, N ;

Kiyosawa, K .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) :732-738

[6] Pancreatic adverse events in patients treated with immune checkpoint inhibitors [J].

Hana, Caroline ;

Rehman, Tauseef ;

Park, Kyeeun ;

Uribe, Carlos Carracedo ;

Aung, Pyi Phyo ;

Hunis, Brian ;

Salzberg, Matthew ;

Zikria, Jennifer ;

Hussein, Atif .

JGH OPEN, 2023, 7 (03) :204-207

[7] Evaluation of rare but severe immune related adverse effects in PD-1 and PD-L1 inhibitors in non-small cell lung cancer: a meta-analysis [J].

Hu, Yang-Bo ;

Zhang, Qun ;

Li, Hui-Juan ;

Michot, Jean Maire ;

Liu, Hong-Bing ;

Zhan, Ping ;

Lv, Tang-Feng ;

Song, Yong .

TRANSLATIONAL LUNG CANCER RESEARCH, 2017, 6 :S8-S20

[8] Prednisolone markedly reduced serum IgG4 levels along with the improvement of pituitary mass and anterior pituitary function in a patient with IgG4-related infundibulohypophysitis [J].

Iseda, Izumi ;

Hida, Kazuyuki ;

Tone, Atsuhiko ;

Tenta, Masafumi ;

Shibata, Yusuke ;

Matsuo, Kiyoshi ;

Yamadori, Ichiro ;

Hashimoto, Kozo .

ENDOCRINE JOURNAL, 2014, 61 (02) :195-203

[9] Japanese Clinical Diagnostic Criteria for Autoimmune Pancreatitis, 2018 Revision of Japanese Clinical Diagnostic Criteria for Autoimmune Pancreatitis, 2011 [J].

Kawa, Shigeyuki ;

Kamisawa, Terumi ;

Notohara, Kenji ;

Fujinaga, Yasunari ;

Inoue, Dai ;

Koyama, Takashi ;

Okazaki, Kazuichi .

PANCREAS, 2020, 49 (01) :E13-E14

[10] Clinical Characteristics of 76 Patients with IgG4-Related Hypophysitis: A Systematic Literature Review [J].

Li, Yujuan ;

Gao, Hua ;

Li, Zhen ;

Zhang, Xinxin ;

Ding, Yizhi ;

Li, Fengao .

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2019, 2019

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