Current Treatment Paradigms for Advanced Melanoma with Brain Metastases

被引：0

作者：

Bonzano, Elisabetta ^{[1
]}

Barruscotti, Stefania ^{[2
]}

Chiellino, Silvia ^{[3
]}

Montagna, Benedetta ^{[3
]}

Bonzano, Chiara ^{[4
]}

Imarisio, Ilaria ^{[3
]}

Colombo, Sara ^{[1
]}

Guerrini, Francesco ^{[5
]}

Saddi, Jessica ^{[1
]}

La Mattina, Salvatore ^{[1
]}

Tomasini, Carlo Francesco ^{[2
]}

Spena, Giannantonio ^{[5
]}

Pedrazzoli, Paolo ^{[3
]}

Lancia, Andrea ^{[1
]}

机构：

[1] Fdn IRCCS Policlin San Matteo, Dept Radiat Oncol, I-27100 Pavia, Italy

[2] Fdn IRCCS Policlin San Matteo, Dermatol Clin, I-27100 Pavia, Italy

[3] Fdn IRCCS Policlin San Matteo, Dept Oncol, Unit Oncol, I-27100 Pavia, Italy

[4] IRCCS Osped Policlin San Martino, Univ Eye Clin, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, I-16132 Genoa, Italy

[5] Fdn IRCCS Policlin San Matteo, Dept Head & Neck Surg, Unit Neurosurg, I-27100 Pavia, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2025年 / 26卷 / 08期

关键词：

melanoma; brain metastases; immunotherapy; targeted therapy; radiotherapy; stereotactic radiosurgery; multidisciplinary treatment; POSTOPERATIVE STEREOTACTIC RADIOSURGERY; STAGE-IV MELANOMA; RADIATION-THERAPY; RADIOTHERAPY; IPILIMUMAB; MANAGEMENT; MULTICENTER; MEMORY;

D O I：

10.3390/ijms26083828

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The therapeutic management of melanoma brain metastases has undergone a profound revolution during recent decades. Optimal integration of systemic therapies with local treatments seems to represent the strategy to pursue in order to maximize clinical outcomes, stressing the need for real multidisciplinary care in this setting of patients. However, the current approach in the clinics does not necessarily reflect what the current guidelines state, and several pending issues are present, from the ideal therapeutic sequence between stereotactic radiosurgery (SRS) and drug administration to the current role of surgery and whole brain radiotherapy (WBRT), all of which need to be addressed. This narrative review aims to provide practical help for navigating the current controversies, with an eye towards possible future advancements in the field, which could help to obtain a comprehensive molecular characterization of the tumor and a more personalized patient-centered therapeutic approach.

引用

页数：16

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