Epigenetic Modifications in Sensorineural Hearing Loss: Protective Mechanisms and Therapeutic Potential

被引：0
作者：
Li, Jia-huan [1 ,2 ,3 ]
Liu, Chang [4 ]
Qiu, Si-yu [1 ,2 ,3 ]
Zheng, Shi-mei [1 ,2 ,3 ]
He, Ying-zi [1 ,2 ,3 ]
机构：
[1] Fudan Univ, ENT Inst, Shanghai 200031, Peoples R China
[2] Fudan Univ, Eye & ENT Hosp, Dept Otorhinolaryngol, Shanghai 200031, Peoples R China
[3] Fudan Univ, NHC Key Lab Hearing Med, Shanghai 200031, Peoples R China
[4] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Otolaryngol Head & Neck Surg, Guangzhou 510630, Peoples R China
来源：
CURRENT MEDICAL SCIENCE | 2025年 / 45卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Sensorineural hearing loss; Hair cell protection; Epigenetic modification; Epigenetic compounds; COCHLEAR HAIR CELL; CISPLATIN-INDUCED OTOTOXICITY; SODIUM-BUTYRATE PROTECTS; HISTONE DEACETYLASES; GENE-EXPRESSION; DNA METHYLATION; NONCODING RNAS; VALPROIC ACID; MOUSE MODEL; APOPTOSIS;
D O I：
10.1007/s11596-025-00049-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hearing loss, which currently affects more than 430 million individuals globally and is projected to exceed 700 million by 2050, predominantly manifests as sensorineural hearing loss (SNHL), for which existing technologies such as hearing aids and cochlear implants fail to restore natural auditory function. Research focusing on protecting inner ear hair cells (HCs) from harmful factors through the regulation of epigenetic modifications has gained significant attention in otology for its role in regulating gene expression without altering the DNA sequence, suggesting potential strategies for preventing and treating SNHL. By synthesizing relevant studies on the inner ear, this review summarizes the emerging roles of histone modifications, DNA methylation, and noncoding RNAs in HC damage, with a focus on their therapeutic potential through epigenetic modulation. Moreover, this review examines the therapeutic potential of epigenetic regulation for the prevention and treatment of SNHL, emphasizing the application of small-molecule epigenetic compounds and their efficacy in modulating gene expression to preserve and restore auditory function.
引用
收藏
页码：415 / 429
页数：15
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