Immune Evasion in Cancer Metastasis: An Unappreciated Role of Monocytes

被引：0
作者：
Patysheva, Marina R. [1 ]
Fedorenko, Anastasya A. [1 ]
Khozyainova, Anna A. [1 ]
Denisov, Evgeny V. [1 ,2 ]
Gerashchenko, Tatiana S. [1 ,2 ]
机构：
[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, Canc Res Inst, Kooperativny Str 5, Tomsk 634009, Russia
[2] RUDN Univ, Peoples Friendship Univ Russia, Res Inst Mol & Cellular Med, Miklukho-Maklaya Str 6, Moscow 115093, Russia
来源：
CANCERS | 2025年 / 17卷 / 10期
基金：
俄罗斯科学基金会;
关键词：
monocyte; immune evasion; metastasis; progression; monocytic myeloid-derived suppressor cell; pre-metastatic niche; tumor hybrid cell; epithelial-mesenchymal plasticity; immunotherapy; TUMOR-ASSOCIATED MACROPHAGES; SUPPRESSOR-CELLS; INFLAMMATORY MONOCYTES; PREMETASTATIC NICHE; PANCREATIC-CANCER; BONE-MARROW; SURVIVAL; RECRUITMENT; MECHANISMS; ANGIOGENESIS;
D O I：
10.3390/cancers17101638
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Metastasis is the leading cause of cancer-related deaths. During the metastatic cascade, cancer cells tightly interact with immune cells influencing each other in the tumor microenvironment and systemically. Monocytes are important components of immune evasion and critical regulators of cancer progression. They circulate through the bloodstream and contribute to the formation of a pro-tumor microenvironment both in the tumor and pre-metastatic niche. Whereas monocyte participation in cancer development and response to therapy has been described extensively, its impact on metastasis remains a completely uncovered area. This review first summarizes data concerning the influence of monocytes on metastasis formation during their presence in the circulation, primary tumor, and pre-metastatic niche. We also highlight the latest examinations into the clinical relevance of targeting monocytes to prevent metastasis.
引用
收藏
页数：21
相关论文
共 145 条
[111]   Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes [J].
Shand, Francis H. W. ;
Ueha, Satoshi ;
Otsuji, Mikiya ;
Koid, Suang Suang ;
Shichino, Shigeyuki ;
Tsukui, Tatsuya ;
Kosugi-Kanaya, Mizuha ;
Abe, Jun ;
Tomura, Michio ;
Ziogas, James ;
Matsushima, Kouji .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (21) :7771-7776
[112]   Recruited monocytic myeloid-derived suppressor cells promote the arrest of tumor cells in the premetastatic niche through an IL-1β-mediated increase in E-selectin expression [J].
Shi, Huifang ;
Zhang, Juechao ;
Han, Xiaoqing ;
Li, Huihan ;
Xie, Mingshu ;
Sun, Yingying ;
Liu, Wenguang ;
Ba, Xueqing ;
Zeng, Xianlu .
INTERNATIONAL JOURNAL OF CANCER, 2017, 140 (06) :1370-1383
[113]   Immunoregulatory Monocyte Subset Promotes Metastasis Associated With Therapeutic Intervention for Primary Tumor [J].
Shibuya, Takumi ;
Kamiyama, Asami ;
Sawada, Hirotaka ;
Kikuchi, Kenta ;
Maruyama, Mayu ;
Sawado, Rie ;
Ikeda, Naoki ;
Asano, Kenichi ;
Kurotaki, Daisuke ;
Tamura, Tomohiko ;
Yoneda, Atsuko ;
Imada, Keisuke ;
Satoh, Takashi ;
Akira, Shizuo ;
Tanaka, Masato ;
Yotsumoto, Satoshi .
FRONTIERS IN IMMUNOLOGY, 2021, 12
[114]   Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy [J].
Sirkis, Daniel W. ;
Solsberg, Caroline Warly ;
Johnson, Taylor P. ;
Bonham, Luke W. ;
Sturm, Virginia E. ;
Lee, Suzee E. ;
Rankin, Katherine P. ;
Rosen, Howard J. ;
Boxer, Adam L. ;
Seeley, William W. ;
Miller, Bruce L. ;
Geier, Ethan G. ;
Yokoyama, Jennifer S. .
GENOME MEDICINE, 2023, 15 (01)
[115]   Targeting of CD163+Macrophages in Inflammatory and Malignant Diseases [J].
Skytthe, Maria K. ;
Graversen, Jonas Heilskov ;
Moestrup, Soren K. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (15) :1-31
[116]   Myeloid-Derived Suppressor Cells Inhibit T-Cell Activation by Depleting Cystine and Cysteine [J].
Srivastava, Minu K. ;
Sinha, Pratima ;
Clements, Virginia K. ;
Rodriguez, Paulo ;
Ostrand-Rosenberg, Suzanne .
CANCER RESEARCH, 2010, 70 (01) :68-77
[117]   Tumor Properties Mediate the Relationship between Peripheral Blood Monocytes and Tumor-Associated Macrophages in Breast Cancer [J].
Stakheyeva, Marina ;
Patysheva, Marina ;
Kaigorodova, Evgenia ;
Zavyalova, Marina ;
Tarabanovskaya, Natalia ;
Choynzonov, Evgeny ;
Cherdyntseva, Nadezhda .
CANCER INVESTIGATION, 2022, 40 (05) :442-456
[118]   Nitric Oxide Production by Myeloid-Derived Suppressor Cells Plays a Role in Impairing Fc Receptor-Mediated Natural Killer Cell Function [J].
Stiff, Andrew ;
Trikha, Prashant ;
Mundy-Bosse, Bethany ;
McMichael, Elizabeth ;
Mace, Thomas A. ;
Benner, Brooke ;
Kendra, Kari ;
Campbell, Amanda ;
Gautam, Shalini ;
Abood, David ;
Landi, Ian ;
Hsu, Vincent ;
Duggan, Megan ;
Wesolowski, Robert ;
Old, Matthew ;
Howard, John Harrison ;
Yu, Lianbo ;
Stasik, Nancy ;
Olencki, Thomas ;
Muthusamy, Natarajan ;
Tridandapani, Susheela ;
Byrd, John C. ;
Caligiuri, Michael ;
Carson, William E. .
CLINICAL CANCER RESEARCH, 2018, 24 (08) :1891-1904
[119]   Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems [J].
Su, Mei-Ju ;
Aldawsari, Hibah ;
Amiji, Mansoor .
SCIENTIFIC REPORTS, 2016, 6
[120]   Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites [J].
Swirski, Filip K. ;
Nahrendorf, Matthias ;
Etzrodt, Martin ;
Wildgruber, Moritz ;
Cortez-Retamozo, Virna ;
Panizzi, Peter ;
Figueiredo, Jose-Luiz ;
Kohler, Rainer H. ;
Chudnovskiy, Aleksey ;
Waterman, Peter ;
Aikawa, Elena ;
Mempel, Thorsten R. ;
Libby, Peter ;
Weissleder, Ralph ;
Pittet, Mikael J. .
SCIENCE, 2009, 325 (5940) :612-616
6789101112131415