Regulatory T cell therapy for Graft-versus-Host Disease

被引：2

作者：

Lysandrou, Memnon ^{[1
,2
,3
]}

Kefala, Dionysia ^{[1
,2
]}

Vinnakota, Janaki Manoja ^{[3
]}

Savvopoulos, Nikolaos ^{[1
,2
]}

Zeiser, Robert ^{[3
]}

Spyridonidis, Alexandros ^{[1
,2
]}

机构：

[1] Univ Patras, Bone Marrow Transplantat Unit, Patras, Greece

[2] Univ Patras, Inst Cell Therapy, Patras, Greece

[3] Albert Ludwigs Univ Freiburg, Med Ctr Univ Freiburg, Fac Med, Dept Med 1, Freiburg, Germany

来源：

BONE MARROW TRANSPLANTATION | 2025年 / 60卷 / 07期

关键词：

IN-VITRO; DIFFERENTIATION; INTERLEUKIN-2; CTLA-4; TR1; TRANSPLANTATION; IMMUNOTHERAPY; GENERATION; PREVENTION; INHIBITION;

D O I：

10.1038/s41409-025-02553-x

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Graft-versus-Host Disease (GvHD) is the main cause of morbidity and mortality of allogeneic hematopoietic cell transplantation (allo-HCT). Conventional immunosuppressive pharmacotherapy remains the backbone of GvHD prevention and treatment with suboptimal outcomes especially for patients with refractory disease. Adoptive immunotherapy with regulatory T-cells (Treg) stands as an alternative approach that aims to restore immune tolerance and circumvent prolonged immunosuppression albeit preserving the beneficial Graft-versus-Leukaemia (GvL) effect. In this review, we summarise recent knowledge on Treg biology, clinical applications of various Tregs subtypes in the setting of GvHD and future endeavours of the field.

引用

页码：933 / 939

页数：7

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