Recent advances in the synthesis of bicyclo[4.1.1]octanes

被引：0
作者：
Dong, Jianyang [1 ,2 ]
Yu, Dejiang [1 ,2 ]
Li, Ting [1 ,2 ]
Xue, Dong [1 ,2 ]
机构：
[1] Shaanxi Normal Univ, Key Lab Appl Surface & Colloid Chem, Minist Educ, Xian 710062, Peoples R China
[2] Shaanxi Normal Univ, Sch Chem & Chem Engn, Xian 710062, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 22期
基金：
中国国家自然科学基金;
关键词：
STRAIN-RELEASE; CYCLOADDITION; BICYCLOBUTANES; CYCLOBUTANES; REACTIVITY; CHEMISTRY; ACCESS;
D O I：
10.1039/d5ob00533g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The exploration of bicyclo[n.1.1]alkanes, known for their intricate chemical diversity and potential as benzene bioisosteres, has garnered significant attention over the past two decades. In particular, the past year has seen the emergence of bicyclo[4.1.1]octanes and their structural analogues as promising bioisosteres for meta-substituted arenes and cis-1,3-disubstituted cyclohexanes. To meet the growing demand for bicyclo[4.1.1]octanes, chemists have recently developed innovative (4 + 3) cycloaddition strategies, leveraging bicyclobutanes (BCBs) and 1,4-dipoles for their synthesis. This review provides a comprehensive evaluation of recent advancements in the synthesis and functionalization of these compounds, emphasizing their scope and underlying mechanisms. Additionally, we highlight the challenges and future prospects of identifying novel reaction pathways to access new functionalized bicyclo[4.1.1]octanes.
引用
收藏
页码：5263 / 5272
页数：10
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