Effect of histone deacetylases on pancreatic physiology and pathology: a review

被引：0
作者：
Song, Xinran [1 ]
Wu, Xiaofeng [2 ]
Yang, Jun [3 ]
Xue, Ran [2 ]
机构：
[1] Capital Med Univ, Beijing 100069, Peoples R China
[2] Peking Univ Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Minist Educ Beijing, Dept Early Drug Dev Ctr, Fucheng Rd 52, Beijing 100142, Peoples R China
[3] Capital Med Univ, Beijing YouAn Hosp, Clin Trial Inst Management Off, 8 Xi Tou Tiao,YouAn Men Wai St, Beijing 100069, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2025年 / 318卷
基金：
中国国家自然科学基金;
关键词：
Histone deacetylases; Pancreas; Pancreatic cancer; Cell biology; Insights; INHIBITOR TRICHOSTATIN-A; CELL-CYCLE ARREST; HDAC INHIBITOR; CLASS-I; ANTITUMOR-ACTIVITY; GENE-EXPRESSION; CANCER CELLS; BETA-CELLS; ADENOCARCINOMA; COMBINATION;
D O I：
10.1016/j.ijbiomac.2025.144837
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The incidence of pancreatic diseases is increasing worldwide. Thus, there is a need to develop novel therapeutic strategies and identify molecular targets for pancreatic diseases. Histone deacetylases (HDACs), which are involved in epigenetic regulation, mediate diverse physiological functions and regulate various vital activities in the pancreas. This review examines the roles of HDACs in different pancreatic cells and the potential therapeutic value of targeting HDACs in pancreatic diseases. Additionally, the potential of HDAC inhibitors as a combination therapy strategy for pancreatic diseases has been discussed, providing novel insights and directions for the diagnosis, treatment, and prevention of pancreatic diseases.
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页数：15
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