Effects of Dietary Supplementation with Maltobionic Acid on Hepatic Lipid Metabolism in Rats Fed a High-Fat Diet

被引：0

作者：

Hara, Seiya ^{[1
]}

Yamada, Chihiro ^{[1
]}

Suehiro, Daiki ^{[2
]}

Fukami, Ken ^{[2
]}

Nakagawa, Tomoyuki ^{[1
,3
]}

Shimada, Masaya ^{[1
,3
,4
]}

机构：

[1] Gifu Univ, Grad Sch Nat Sci & Technol, Dept Life Sci & Chem, Div Life Sci Food, 1-1 Yanagido, Gifu, Gifu 5011193, Japan

[2] San Ei Sucrochem Co Ltd, 24-5 Kitahama Cho, Chita, Aichi 4788503, Japan

[3] Gifu Univ, Inst Adv Study, Preempt Food Res Ctr, 1-1 Yanagido, Gifu, Gifu 5011193, Japan

[4] Gifu Univ, Fac Appl Biol Sci, Dept Appl Life Sci, 1-1 Yanagido, Gifu, Gifu 5011193, Japan

来源：

JOURNAL OF OLEO SCIENCE | 2025年 / 74卷 / 06期

关键词：

fatty acid synthesis; high-fat diet; liver; maltobionic acid; INSULIN SENSITIVITY; OLIGOFRUCTOSE; SECRETION; EXPRESSION; MICROBIOTA; HEALTH; CELLS; FIBER;

D O I：

10.5650/jos.ess25036

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We examined the effects of dietary supplementation with 5% maltobionic acid (MA), an indigestible disaccharide, on hepatic lipid metabolism in rats fed a high-fat diet for 30 days. Supplementation with MA lowered hepatic and serum triacylglycerol (TAG) levels and homeostasis model assessment for insulin resistance and elevated serum gastric hormone glucagonlike peptide-1 (GLP-1) level. MA supplementation remarkably decreased the hepatic expression of fatty acid synthesis-related genes/proteins and slightly increased the hepatic expression of beta oxidation-related genes. These results suggest that MA reduces hepatic TAG levels, probably via the suppression of fatty acid synthesis, accompanied by decreased hyperinsulinemia and increased GLP-1.

引用

页码：543 / 549

页数：7

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