Lymphatic-immune interactions in the musculoskeletal system

被引：0

作者：

Liu, Hanyu ^{[1
]}

Liu, Lu ^{[1
]}

Zhang, Yuheng ^{[1
]}

Tian, Qi ^{[1
]}

Ding, Zhangfan ^{[1
,2
]}

Chen, Junyu ^{[1
,3
]}

Kusumbe, Anjali P. ^{[1
,4
]}

机构：

[1] Nanyang Technol Univ, Lee Kong Chian Sch Med, Tissue & Tumor Microenvironm Lab, Singapore, Singapore

[2] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Dept Head & Neck Oncol,State Key Lab Oral Dis,Natl, Chengdu, Peoples R China

[3] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Dept Prosthodont,State Key Lab Oral Dis,Natl Ctr S, Chengdu, Peoples R China

[4] Univ Coimbra, Multidisciplinary Inst Ageing MIA Portugal, Coimbra, Portugal

来源：

FRONTIERS IN IMMUNOLOGY | 2025年 / 16卷

基金：

欧洲研究理事会;

关键词：

lymphatics; immune; bone; aging; musculoskeletal; THERAPEUTIC INTERVENTION; RHEUMATOID-ARTHRITIS; INTERSTITIAL FLUID; GROWTH-FACTOR; BONE-MARROW; VESSELS; LYMPHANGIOGENESIS; PATHOGENESIS; INFLAMMATION; DRAINAGE;

D O I：

10.3389/fimmu.2025.1578847

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Traditionally, the role of lymphatic vessels has been understood as primarily involving fluid transport and immune surveillance. In addition to these roles, recent studies have revealed a paracrine function of lymphatics through the dissemination of inductive factors, known as lymphangiocrine signals including in musculoskeletal physiology and diseases. These signals play diverse roles, including maintaining tissue equilibrium and facilitating regeneration. Impaired lymphangiocrine signaling and lymphatic function are features of musculoskeletal diseases. This review summarizes dysregulation of lymphatic vessels and interactions with immune cells during musculoskeletal diseases. Further, this review provides insights into lymphangiocrine signals as a potential therapeutic target.

引用

页数：13

共 139 条

[1] Rheumatoid arthritis and osteoimmunology: The adverse impact of a deregulated immune system on bone metabolism [J].

Andreev, Darja ;

Kachler, Katerina ;

Schett, Georg ;

Bozec, Aline .

BONE, 2022, 162

[2] Effect of lymphedema on the recovery of fractures [J].

Arslan, Hueseyin ;

Uludag, Abuzer ;

Kapukaya, Ahmet ;

Gezici, Ayten ;

Bekler, H. Ibrahim ;

Ketani, Aydin .

JOURNAL OF ORTHOPAEDIC SCIENCE, 2007, 12 (06) :578-584

[3] Altered Lymphatic Vessel Anatomy and Markedly Diminished Lymph Clearance in Affected Hands of Patients With Active Rheumatoid Arthritis [J].

Bell, Richard D. ;

Rahimi, Homaira ;

Kenney, H. Mark ;

Lieberman, Alicia A. ;

Wood, Ronald W. ;

Schwarz, Edward M. ;

Ritchlin, Christopher T. .

ARTHRITIS & RHEUMATOLOGY, 2020, 72 (09) :1447-1455

[4] iNOS dependent and independent phases of lymph node expansion in mice with TNF-induced inflammatory-erosive arthritis [J].

Bell, Richard D. ;

Slattery, Pamelia N. ;

Wu, Emily K. ;

Xing, Lianping ;

Ritchlin, Christopher T. ;

Schwarz, Edward M. .

ARTHRITIS RESEARCH & THERAPY, 2019, 21 (01)

[5] Lymphangiogenesis and Lymphatic Function in Periodontal Disease [J].

Berggreen, E. ;

Wiig, H. .

JOURNAL OF DENTAL RESEARCH, 2013, 92 (12) :1074-1080

[6] Age-related bone diseases: Role of inflammaging [J].

Bi, Jiaming ;

Zhang, Caimei ;

Lu, Caihong ;

Mo, Chuzi ;

Zeng, Jiawei ;

Yao, Mingyan ;

Jia, Bo ;

Liu, Zhongjun ;

Yuan, Peiyan ;

Xu, Shuaimei .

JOURNAL OF AUTOIMMUNITY, 2024, 143

[7] Tumor necrosis factorinhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factordriven model of rheumatoid arthritis [J].

Binder, Nikolaus B. ;

Puchner, Antonia ;

Niederreiter, Birgit ;

Hayer, Silvia ;

Leiss, Harald ;

Blueml, Stephan ;

Kreindl, Roman ;

Smolen, Josef S. ;

Redlich, Kurt .

ARTHRITIS AND RHEUMATISM, 2013, 65 (03) :608-617

[8] Lymphatic vessels in bone support regeneration after injury [J].

Biswas, Lincoln ;

Chen, Junyu ;

De Angelis, Jessica ;

Singh, Amit ;

Owen-Woods, Charlotte ;

Ding, Zhangfan ;

Pujol, Joan Mane ;

Kumar, Naveen ;

Zeng, Fanxin ;

Ramasamy, Saravana K. ;

Kusumbe, Anjali P. .

CELL, 2023, 186 (02) :382-+

[9]

BLANCO FJ, 1995, AM J PATHOL, V146, P75

[10] Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis [J].

Bouta, Echoe M. ;

Bell, Richard D. ;

Rahimi, Homaira ;

Xing, Lianping ;

Wood, Ronald W. ;

Bingham, Clifton O., III ;

Ritchlin, Christopher T. ;

Schwarz, Edward M. .

NATURE REVIEWS RHEUMATOLOGY, 2018, 14 (02) :94-106

← 1 2 3 4 5 6 7 8 9 10 →