Revolution of Circulating Tumor DNA: From Bench Innovations to Bedside Implementations

被引：0

作者：

Yan, Xuehan ^{[1
]}

Su, Juncheng ^{[1
]}

Wang, Zheng ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Renji Hosp, Dept Gastrointestinal Surg, Sch Med, Shanghai 200127, Peoples R China

来源：

CURRENT ISSUES IN MOLECULAR BIOLOGY | 2025年 / 47卷 / 06期

基金：

中国国家自然科学基金;

关键词：

ctDNA; cancer; detection method; clinical application; CELL-FREE DNA; RESIDUAL DISEASE; LIQUID BIOPSIES; PROSTATE-CANCER; BLOOD-PLASMA; LUNG-CANCER; CTDNA; HALLMARKS; RECOMMENDATIONS; VALIDATION;

D O I：

10.3390/cimb47060428

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Circulating tumor DNA (ctDNA), a newly developed cancer biomarker, consists of single- or double-stranded DNA fragments that are shed from tumor cells in primary or metastatic sites. They are released into peripheral blood and exhibit distinct characteristics associated with cancer, even in the early stages. With advancements in technology, ctDNA detection has become more diverse and precise, including digital Polymerase Chain Reaction (dPCR) and next-generation sequencing (NGS), among others. As a chronic disease that develops over an extended period, early detection is crucial for the accurate diagnosis and treatment of cancer and can significantly improve patient prognosis. Therefore, analyzing ctDNA features is important. Additionally, ctDNA can be used to assess post-surgical minimal residual disease (MRD), aiding in treatment decisions. Overall, ctDNA plays a crucial role in the progression of cancer and its treatment. This review summarizes the sources and features of ctDNA, the analytical techniques used, and its application in both solid and non-solid tumors.

引用

页数：19

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