The relationship between 10-year changes in cognitive ability and subsequent mortality: findings from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial

被引：2

作者：

Chen, Diefei ^{[1
,2
]}

Gross, Alden L. ^{[1
,2
]}

Parisi, Jeanine M. ^{[3
]}

Willis, Sherry L. ^{[4
]}

Felix, Cynthia ^{[5
]}

Thorpe Jr, Roland J. ^{[6
,7
]}

Marsiske, Michael ^{[8
]}

Thomas, Kelsey R. ^{[9
,10
]}

Huang, Alison R.

Rebok, George W. ^{[1
,2
,3
,7
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA

[2] Johns Hopkins Ctr Aging & Hlth, Dept Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD USA

[4] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA USA

[5] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA

[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD USA

[7] Johns Hopkins Alzheimers Dis Resource Ctr Minor Ag, Baltimore, MD USA

[8] Univ Florida, Dept Psychol, Gainesville, FL USA

[9] VA San Diego Healthcare Syst, Res Serv, San Diego, CA USA

[10] Univ Calif San Diego, Dept Psychiat, San Diego, CA USA

来源：

AMERICAN JOURNAL OF EPIDEMIOLOGY | 2025年 / 194卷 / 07期

基金：

美国国家卫生研究院;

关键词：

cognitive training; cognition; cognitive decline; mortality; OLDER-ADULTS; ALZHEIMERS-DISEASE; MEMORY; IMPAIRMENT; AGE; DECLINE; INTERVENTIONS; ASSESSMENTS; CHALLENGES; RECOVERY;

D O I：

10.1093/aje/kwae381

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Cognitive ability and cognitive decline are related to mortality in older adults. Cognitive interventions have been found to improve cognitive performance and slow cognitive decline in later life. However, the longitudinal effects of cognitive interventions on mortality in older adults remain unclear. Using 20-year follow-up data from the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) trial, we examined the association between cognitive trajectory (ie, intercept, slope, and retest effect) and mortality using shared growth-survival models. We evaluated the effect of ACTIVE cognitive training (memory, reasoning, and speed of processing) on mortality risk. Among the 2802 participants, 2021 died in or before the year 2019 (72.1%). Higher baseline, slower decline, and greater retest effects in general cognitive performance were associated with lower mortality risk after adjusting for covariates. Associations with mortality were similar, contrasting general and domain-specific cognitive abilities. We did not observe any significant effects of ACTIVE cognitive training in memory, reasoning, or speed of processing on all-cause mortality. Our findings suggest cognitive training interventions do not have a significant effect on cognitive trajectory and mortality among older adults; rather, older adults with higher education tend to incur greater survival benefits from memory training.

引用

页码：1967 / 1975

页数：9

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