The gold complex auranofin sensitizes platinum resistant epithelial ovarian cancer cells to cisplatin

被引：0
作者：
Abdalbari, Farah H. [1 ]
Forgie, Benjamin N. [1 ]
Zorychta, Edith [1 ]
Goyeneche, Alicia A. [1 ,2 ]
Noman, Abu Shadat M. [3 ,4 ]
Telleria, Carlos M. [1 ,2 ,5 ]
机构：
[1] McGill Univ, Fac Med & Hlth Sci, Dept Pathol, Expt Pathol Unit, Montreal, PQ H3A 2B4, Canada
[2] McGill Univ, Res Inst, Hlth Ctr, Canc Res Program, Montreal, PQ H4A 3J1, Canada
[3] Univ Chittagong, Dept Biochem & Mol Biol, Chittagong, Bangladesh
[4] McGill Univ, Fac Med & Hlth Sci, Dept Pharmacol & Therapeut, Montreal, PQ H3A 2B4, Canada
[5] McGill Univ, Fac Med & Hlth Sci, Gerald Bronfman Dept Oncol, Montreal, PQ H4A 3T2, Canada
来源：
BIOCHEMISTRY AND BIOPHYSICS REPORTS | 2025年 / 42卷
关键词：
Ovarian cancer; Auranofin; Cisplatin; Reactive oxygen species; Intrinsic apoptosis; DNA damage; MARKER; DRUGS; DNA;
D O I：
10.1016/j.bbrep.2025.101996
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although numerous drugs have been tested to treat ovarian cancer (OC), survival rates remain low as there has been no major improvement from platinum (Pt)-based therapy and there is a high rate of Pt resistance in these tumors. Following several rounds of chemotherapy, OC cells develop Pt-resistance by increasing DNA repair and antioxidant defense mechanisms. This study aimed to design a treatment to combat recurrent stages of OC by repurposing the anti-rheumatic gold complex auranofin (AF). We demonstrate that AF enhances the efficacy of cisplatin (CDDP) in Pt-resistant epithelial OC (EOC) cells. The drug combination enhanced mitochondrialdependent apoptosis, PARP cleavage, DNA damage, and ROS overproduction. These results suggest the potential to combine AF with CDDP as a strategy to improve CDDP sensitivity in recurrent EOCs.
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页数：7
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