Locally advanced thoracic NUT carcinoma - a case report and literature review

被引：0

作者：

Chilczuk, Piotr A. ^{[1
]}

Knetki-Wroblewska, Magdalena ^{[1
]}

机构：

[1] Maria Sklodowska Curie Natl Inst Oncol, Dept Lung Canc & Chest Tumours, Warsaw, Poland

来源：

ONCOLOGY IN CLINICAL PRACTICE | 2024年

关键词：

NUT; NUT carcinoma; gene rearrangement; MIDLINE CARCINOMA;

D O I：

10.5603/ocp.101460

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

NUT carcinoma is an extremely rare and aggressive cancer. It is characterised by the presence of a nuclear protein gene rearrangement (NUTM1) on chromosome 15q14. Nut carcinoma can occur at any age but mainly in third decade. Patients with NUT carcinoma have affects diffrent organs, mainly in the midline of the body. Average overall survival patients with nut carcinoma does not exceed one year. The very rapid course of the disease, non-specific symptoms and the lack of specific treatment guidelines constitute a therapeutic challenge for oncologists. New treatment standards are needed. In our case report, we proposed a treatment method that showed clinical benefit

引用

页数：4

共 9 条

[1] The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains [J].

Alekseyenko, Artyom A. ;

Walsh, Erica M. ;

Wang, Xin ;

Grayson, Adlai R. ;

Hsi, Peter T. ;

Kharchenko, Peter V. ;

Kuroda, Mitzi I. ;

French, Christopher A. .

GENES & DEVELOPMENT, 2015, 29 (14) :1507-1523

[2] Nuclear protein in testis carcinoma of the lung [J].

Chen, Jing ;

Li, Meihui ;

Lu, Hongyang .

TRANSLATIONAL ONCOLOGY, 2023, 30

[3] NUT Carcinoma: Clinicopathologic features, pathogenesis, and treatment [J].

French, Christopher A. .

PATHOLOGY INTERNATIONAL, 2018, 68 (11) :583-595

[4] Patterns of care and impact of prognostic factors in the outcome of NUT midline carcinoma: a systematic review and individual patient data analysis of 119 cases [J].

Giridhar, Prashanth ;

Mallick, Supriya ;

Kashyap, Lakhan ;

Rath, Goura Kishor .

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2018, 275 (03) :815-821

[5] NUT midline carcinoma of the larynx: an international series and review of the literature [J].

Hellquist, Henrik ;

French, Christopher A. ;

Bishop, Justin A. ;

Coca-Pelaz, Andres ;

Propst, Evan J. ;

Correia, Antonio Paiva ;

Ngan, Bo-Yee ;

Grant, Ronald ;

Cipriani, Nicole A. ;

Vokes, David ;

Henrique, Rui ;

Pardal, Fernando ;

Vizcaino, Jose Ramon ;

Rinaldo, Alessandra ;

Ferlito, Alfio .

HISTOPATHOLOGY, 2017, 70 (06) :861-868

[6] Clinical management of NUT carcinoma (NC) in Germany: Analysis of survival, therapy response, tumor markers and tumor genome sequencing in 35 adult patients [J].

Kloker, Linus D. ;

Sidiras, Mirjana ;

Flaadt, Tim ;

Brecht, Ines B. ;

Deinzer, Christoph K. W. ;

Gro, Thorben ;

Benzler, Katrin ;

Zender, Lars ;

Lauer, Ulrich M. .

LUNG CANCER, 2024, 189

[7] NUT Carcinoma-An Underdiagnosed Malignancy [J].

Lauer, Ulrich M. ;

Hinterleitner, Martina ;

Horger, Marius ;

Ohnesorge, Paul V. ;

Zender, Lars .

FRONTIERS IN ONCOLOGY, 2022, 12

[8] Initial Chemotherapy for Locally Advanced and Metastatic NUT Carcinoma [J].

Luo, Jia ;

Sanchez, Michelle ;

Lee, Elinton ;

Hertzler, Hans ;

Luong, Nhi ;

Mazzola, Emanuele ;

Finstein, Bryanna ;

Tamen, Rubii ;

Brisbane, Gifty ;

Nguyen, Tom ;

Paik, Paul K. ;

Chaft, Jamie E. ;

Cheng, Michael L. ;

Khalil, Hassan ;

Piha-Paul, Sarina A. ;

Sholl, Lynette M. ;

Nishino, Mizuki ;

Janne, Pasi A. ;

DuBois, Steven G. ;

Hanna, Glenn J. ;

Shapiro, Geoffrey I. ;

French, Christopher A. .

JOURNAL OF THORACIC ONCOLOGY, 2024, 19 (05) :829-838

[9] Diagnosis, Treatment and Prognosis of Primary Pulmonary NUT Carcinoma: A Literature Review [J].

Yuan, Jiaqian ;

Xu, Zhili ;

Guo, Yong .

CURRENT ONCOLOGY, 2022, 29 (10) :6807-6815

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