NMDA Receptors: Next therapeutic targets for Tinnitus?

被引：0
作者：
Che, Chenhao
Wu, Yongzhen
Sun, Shan
机构：
[1] Fudan Univ, ENT Inst, Shanghai 200031, Peoples R China
[2] Fudan Univ, Otorhinolaryngol Dept, State Key Lab Med Neurobiol, Eye & ENT Hosp, Shanghai 200031, Peoples R China
[3] Fudan Univ, MOE Frontiers Ctr Brain Sci, Shanghai 200031, Peoples R China
来源：
BIOCHEMISTRY AND BIOPHYSICS REPORTS | 2025年 / 42卷
基金：
中国国家自然科学基金;
关键词：
Tinnitus; Drug therapy; NMDAR antagonist; Tinnitus pathology; Glutamate receptor; SALICYLATE-INDUCED TINNITUS; SYNAPTIC PLASTICITY; ARACHIDONIC-ACID; COCHLEAR NUCLEUS; STRUCTURAL BASIS; HEARING-LOSS; MECHANISMS; AMPA; PREVALENCE; EXPRESSION;
D O I：
10.1016/j.bbrep.2025.102029
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tinnitus, a common otological symptom, lacks clinically approved pharmacological treatments, highlighting an urgent unmet need. This review explores the potential role of NMDARs, key glutamate receptors in the auditory system, in tinnitus pathophysiology, including excitotoxicity, synaptic plasticity, and neuropathic pain. Alterations in NMDAR variants with different subunit compositions during development have also been implicated in the onset of tinnitus. Clinical trials of NMDAR antagonists, such as acamprosate, caroverine, neramexane, and AM-101, have shown promising results, though none are yet approved. These findings highlight the need for further research on NMDARs to advance the development of next-generation targeted pharmacological therapies for tinnitus.
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页数：11
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