E-Cadherin: A conductor of cellular signaling

被引：0

作者：

Kehrberg, Rachel J. ^{[1
]}

DeMali, Kris A. ^{[1
]}

机构：

[1] Univ Iowa, Roy J & Lucille A Carver Coll Med, Dept Biochem & Mol Biol, 51 Newton Rd, Iowa City, IA 52242 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2025年 / 95卷

基金：

美国国家卫生研究院;

关键词：

ALPHA-CATENIN; PHOSPHATIDYLINOSITOL; 3-KINASE; TYROSINE PHOSPHORYLATION; MECHANICAL FORCE; ADHESION; ACTIVATION; VINCULIN; RAC; RHO; MECHANOTRANSDUCTION;

D O I：

10.1016/j.ceb.2025.102559

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Upon engagement of E-cadherin or when mechanical force is applied, E-cadherin recruits cytoskeletal proteins and triggers various signal transduction cascades including PI3K, Src, Rho family GTPases, kinases, YAP/TAZ, AMPK, and other metabolic enzymes. These cascades modulate E-cadherin's stability, viscosity, and its connection to the actin cytoskeleton, thereby reinforcing cell-cell adhesion.

引用

页数：9

共 83 条

[51] Myosin-IXA Regulates Collective Epithelial Cell Migration by Targeting RhoGAP Activity to Cell-Cell Junctions [J].

Omelchenko, Tatiana ;

Hall, Alan .

CURRENT BIOLOGY, 2012, 22 (04) :278-288

[52] Assessment of cancer cell migration using a viscosity-sensitive fluorescent probe [J].

Pan, Xiaohong ;

Wang, Cheng ;

Zhao, Congcong ;

Cheng, Tingting ;

Zheng, Aishan ;

Cao, Yuru ;

Xu, Kehua .

CHEMICAL COMMUNICATIONS, 2022, 58 (29) :4663-4666

[53] Activation of the protein kinase Akt PKB by the formation of E-cadherin-mediated cell-cell junctions - Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex [J].

Pece, S ;

Chiariello, M ;

Murga, C ;

Gutkind, JS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (27) :19347-19351

[54] α-Catenin Uses a Novel Mechanism to Activate Vinculin [J].

Peng, Xiao ;

Maiers, Jessica L. ;

Choudhury, Dilshad ;

Craig, Susan W. ;

Demali, Kris A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (10) :7728-7737

[55] Vinculin regulates cell-surface E-cadherin expression by binding to β-catenin [J].

Peng, Xiao ;

Cuff, Laura E. ;

Lawton, Cort D. ;

DeMali, Kris A. .

JOURNAL OF CELL SCIENCE, 2010, 123 (04) :567-577

[56] Multivalent interactions make adherens junction-cytoskeletal linkage robust during morphogenesis [J].

Perez-Vale, Kia Z. ;

Yow, Kristi D. ;

Johnson, Ruth, I ;

Byrnes, Amy E. ;

Finegan, Tara M. ;

Slep, Kevin C. ;

Peifer, Mark .

JOURNAL OF CELL BIOLOGY, 2021, 220 (12)

[57] RhoA is down-regulated at cell-cell contacts via p190RhoGAP-B in response to tensional homeostasis [J].

Ponik, Suzanne M. ;

Trier, Steven M. ;

Wozniak, Michele A. ;

Eliceiri, Kevin W. ;

Keely, Patricia J. .

MOLECULAR BIOLOGY OF THE CELL, 2013, 24 (11) :1688-1699

[58] Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions [J].

Priya, Rashmi ;

Gomez, Guillermo A. ;

Budnar, Srikanth ;

Verma, Suzie ;

Cox, Hayley L. ;

Hamilton, Nicholas A. ;

Yap, Alpha S. .

NATURE CELL BIOLOGY, 2015, 17 (10) :1282-+

[59] The Scribble-SGEF-Dlg1 complex regulates E-cadherin and ZO-1 stability, turnover and transcription in epithelial cells [J].

Rabino, Agustin ;

Awadia, Sahezeel ;

Ali, Nabaa ;

Edson, Amber ;

Garcia-Mata, Rafael .

JOURNAL OF CELL SCIENCE, 2024, 137 (19)

[60] Assembly of Peripheral Actomyosin Bundles in Epithelial Cells Is Dependent on the CaMKK2/AMPK Pathway [J].

Rajakyla, Eeva Kaisa ;

Lehtimaki, Jaakko, I ;

Acheva, Anna ;

Schaible, Niccole ;

Lappalainen, Pekka ;

Krishnan, Ramaswamy ;

Tojkander, Sari .

CELL REPORTS, 2020, 30 (12) :4266-+

← 1 2 3 4 5 6 7 8 9 →