E-Cadherin: A conductor of cellular signaling

被引：0
作者：
Kehrberg, Rachel J. [1 ]
DeMali, Kris A. [1 ]
机构：
[1] Univ Iowa, Roy J & Lucille A Carver Coll Med, Dept Biochem & Mol Biol, 51 Newton Rd, Iowa City, IA 52242 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2025年 / 95卷
基金：
美国国家卫生研究院;
关键词：
ALPHA-CATENIN; PHOSPHATIDYLINOSITOL; 3-KINASE; TYROSINE PHOSPHORYLATION; MECHANICAL FORCE; ADHESION; ACTIVATION; VINCULIN; RAC; RHO; MECHANOTRANSDUCTION;
D O I：
10.1016/j.ceb.2025.102559
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Upon engagement of E-cadherin or when mechanical force is applied, E-cadherin recruits cytoskeletal proteins and triggers various signal transduction cascades including PI3K, Src, Rho family GTPases, kinases, YAP/TAZ, AMPK, and other metabolic enzymes. These cascades modulate E-cadherin's stability, viscosity, and its connection to the actin cytoskeleton, thereby reinforcing cell-cell adhesion.
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页数：9
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