E-Cadherin: A conductor of cellular signaling

被引：0

作者：

Kehrberg, Rachel J. ^{[1
]}

DeMali, Kris A. ^{[1
]}

机构：

[1] Univ Iowa, Roy J & Lucille A Carver Coll Med, Dept Biochem & Mol Biol, 51 Newton Rd, Iowa City, IA 52242 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2025年 / 95卷

基金：

美国国家卫生研究院;

关键词：

ALPHA-CATENIN; PHOSPHATIDYLINOSITOL; 3-KINASE; TYROSINE PHOSPHORYLATION; MECHANICAL FORCE; ADHESION; ACTIVATION; VINCULIN; RAC; RHO; MECHANOTRANSDUCTION;

D O I：

10.1016/j.ceb.2025.102559

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Upon engagement of E-cadherin or when mechanical force is applied, E-cadherin recruits cytoskeletal proteins and triggers various signal transduction cascades including PI3K, Src, Rho family GTPases, kinases, YAP/TAZ, AMPK, and other metabolic enzymes. These cascades modulate E-cadherin's stability, viscosity, and its connection to the actin cytoskeleton, thereby reinforcing cell-cell adhesion.

引用

页数：9

共 83 条

[1]

ABERLE H, 1994, J CELL SCI, V107, P3655

[2] A Mechanosensitive RhoA Pathway that Protects Epithelia against Acute Tensile Stress [J].

Acharya, Bipul R. ;

Nestor-Bergmann, Alexander ;

Liang, Xuan ;

Gupta, Shafali ;

Duszyc, Kinga ;

Gauquelin, Estelle ;

Gomez, Guillermo A. ;

Budnar, Srikanth ;

Marcq, Philippe ;

Jensen, Oliver E. ;

Bryant, Zev ;

Yap, Alpha S. .

DEVELOPMENTAL CELL, 2018, 47 (04) :439-+

[3] RAC1 regulates adherens junctions through endocytosis of E-cadherin [J].

Akhtar, N ;

Hotchin, NA .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (04) :847-862

[4] IRF6 Regulates the Delivery of E-Cadherin to the Plasma Membrane [J].

Antiguas, Angelo ;

DeMali, Kris A. ;

Dunnwald, Martine .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2022, 142 (02) :314-322

[5]

Arora A, 2023, bioRxiv

[6] Multi-level Force-dependent Allosteric Enhancement of aE-catenin Binding to F-actin by Vinculin [J].

Bax, Nicolas A. ;

Wang, Amy ;

Huang, Derek L. ;

Pokutta, Sabine ;

Weis, William I. ;

Dunn, Alexander R. .

JOURNAL OF MOLECULAR BIOLOGY, 2023, 435 (05)

[7] Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK [J].

Bays, Jennifer L. ;

Campbell, Hannah K. ;

Heidema, Christy ;

Sebbagh, Michael ;

DeMali, Kris A. .

NATURE CELL BIOLOGY, 2017, 19 (06) :724-+

[8] Vinculin phosphorylation differentially regulates mechanotransduction at cell-cell and cell-matrix adhesions [J].

Bays, Jennifer L. ;

Peng, Xiao ;

Tolbert, Catlin E. ;

Guilluy, Christophe ;

Angell, Ashley E. ;

Pan, Yuan ;

Superfine, Richard ;

Burridge, Keith ;

DeMali, Kris A. .

JOURNAL OF CELL BIOLOGY, 2014, 205 (02) :251-263

[9] α-Catenin-dependent vinculin recruitment to adherens junctions is antagonistic to focal adhesions [J].

Bejar-Padilla, Vidal ;

Cabe, Jolene, I ;

Lopez, Santiago ;

Narayanan, Vani ;

Mezher, Mazen ;

Maruthamuthu, Venkat ;

Conway, Daniel E. .

MOLECULAR BIOLOGY OF THE CELL, 2022, 33 (11)

[10] Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry [J].

Benham-Pyle, Blair W. ;

Pruitt, Beth L. ;

Nelson, W. James .

SCIENCE, 2015, 348 (6238) :1024-1027

← 1 2 3 4 5 6 7 8 9 →